**4. Conclusions**

In the present work, the efficiency of PLE extraction for the recovery of phytochemicals from artichoke by-products was studied. The proposed extraction system by PLE obtained 9 extracts under different extraction conditions delimited by the technical limits of the PLE extractor. The analytical characterization of these extracts allowed the detection of 23 compounds, most of them were phenolic and other polar bioactive compounds previously identified in artichoke samples. The individual phenolic compounds recovery through the different PLE extraction conditions was estimated by considering the peak area of each compound in the chromatogram (three replicates), which permits a comparison of the same compound between extracts. This information could establish the best extraction condition for each compound or family. The best PLE parameters, for both phenolic acids and flavonoids, consist in high percentages of ethanol and medium-high temperatures. In addition, it should be pointed into light that at the same temperature, the recovery of individual phenolic compounds is improved when the solvent composition provides the lowest value of dielectric constant.

**Supplementary Materials:** The following are available online at https://www.mdpi.com/article/10 .3390/app11093788/s1, Table S1: Peak areas of the identified compounds in *C. scolymus* pressurized liquid extraction (PLE), extracts expressed as mean ± standard deviation of the three analyses replicates. Table S2: Statistical data of the PLE extraction conditions for individual phenolic compounds.

**Author Contributions:** Conceptualization, J.L.-S. and I.B.-L.; methodology, J.L.-S. and R.G.-M.; software, L.L.-S.; validation, J.L.-S., I.B.-L. and A.S.-C.; formal analysis, L.L.-S.; investigation, L.L.-S., P.G.-G. and D.Q.; data curation, L.L.-S.; writing—original draft preparation, L.L.-S.; writing—review and editing, J.L.-S. and I.B.-L.; visualization, R.G.-M.; supervision, J.L.-S., A.S.-C. and R.G.-M. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding. **Institutional Review Board Statement:** Not applicable.

**Informed Consent Statement:** Not applicable.

**Data Availability Statement:** All the data generated by this research have been included in the article. For any assistance it is possible to contact with the corresponding author.

**Conflicts of Interest:** The authors declare no conflict of interest.
