*4.1. Mice*

Wild-type Balb/C (WT) mice were purchased from the Federal University of Minas Gerais (UFMG), and ST2 KO (kindly provided by Dr. José Carlos Alves-Filho, Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Brazil). Genetically deficient and control mice were maintained at our facilities and used at 6–8 weeks of age. Mice were housed in filter-top cages and provided with sterile water and food ad libitum. Groups of 5 to 7 animals were used to perform all experiments. The procedures for animal experimentation were approved by the Ethics Committee for the Use of Animals of the Federal University of Minas Gerais—CEUA/UFMG under protocol number 273/2017.
