*2.3. Examples of HFS and GS in Lung Cancer Patients with Pre-Existing ILD*

Two representative patients were evaluated using the HFS (Figure 1). Regarding the HFS, Patient A scored 104 points, and patient B scored 122.5 points. The details are provided in Figure 1. Regarding the GS, patient A scored 0 points according to the two pulmonologists. Patient B was awarded 18 points by Dr. H.G. Each of six lung fields was evaluated as score 3; 3 × 6 = 18. In contrast, Patient B was awarded 15 points by Dr. H.I. Overall, patient B received an average GS of 16.5, indicating severe emphysema.

**Figure 1.** Imaging findings in two representative patients evaluated using the high-resolution computed tomography fibrosis score. The black arrows indicate reticular abnormality (score 2). Patient A scored 104 points, and patient B scored 122.5 points. The scoring of each patient was as follows: Patient A scored 105 points, as evaluated by Dr. H.G. In detail, the (**A-1**) right field was evaluated as 100% of score 1; 100 × 1 = 100. The A-1 left, (**A-2**) right, (**A-2**) left, and (**A-3**) right fields were evaluated as 95% of score 1 and 5% of score 2; (95 × 1) + (5 × 2) = 105. The (**A-3**) left field was evaluated as 90% of score 1 and 10% of score 2; (90 × 1) + (10 × 2) = 110. Thus, the HFS was (100 × 1 + 105 × 4 + 110 × 1)/6 = 105. In contrast, patient A scored 103 points, as evaluated by Dr. H.I. Overall, patient A received an average high-resolution computed tomography fibrosis score (HFS) of 104. Patient B scored 125 points, as evaluated by Dr. H.G. In detail, the (**B-1**) left were evaluated as 80% of score 1 and 20% of score 2; (80 × 1) + (20 × 2) = 120. The (**B-1**) right, (**B-2**) right and left, and (**B-3**) left were evaluated as 75% of score 1 and 25% of score 2; (75 × 1) + (25 × 2) = 125. The (**B-3**) right was evaluated as 70% of score 1 and 30% of score 2; (70 × 1) + (30 × 2) = 130. Thus, the HFS was (120 × 1 + 125 × 4 + 130 × 1)/6 = 125. In contrast, patient B scored 120 points, as evaluated by Dr. H.I. Overall, patient A received an average HFS of 122.5.
