**5. Conclusions**

Our observations suggest that a poor ECOG-PS and a low BMI at the time of intervention with ICI rechallenge may be useful as negative predictors for ICI rechallenge treatment in patients with NSCLC. As this retrospective study was a relatively small-scale study, further experiments are needed to validate the observations.

**Author Contributions:** Conceptualization, Y.K. (Yuki Katayama), T.Y. (Tadaaki Yamada) and K.T.; methodology, Y.K. (Yuki Katayama); validation, Y.K. (Yuki Katayama), T.S. and T.Y.( Tadaaki Yamada); formal analysis, Y.K. (Yuki Katayama); investigation, Y.K. (Yuki Katayama); resources, T.S., T.Y. (Tadaaki Yamada), T.T., T.Y. (Takahiro Yamada), S.S., Y.C., O.H., M.I., Y.K. (Yoshiko Kaneko), J.U. and K.T.; writing—original draft preparation, Y.K. (Yuki Katayama), T.S. and T.Y. (Tadaaki Yamada); supervision, T.Y. (Tadaaki Yamada); project administration, T.Y. (Tadaaki Yamada). All authors have read and agreed to the published version of the manuscript.

**Conflicts of Interest:** The authors declare no conflict of interest.
