*2.1. Eligibility*

Patients were enrolled in this study if they met the following eligibility criteria: cytologically or histologically confirmed diagnosis of incurable, previously treated non-small cell lung cancer; no previous use of docetaxel or uracil plus tegafur (UFT); age between 20–75 years; performance status of ≤1 on the Eastern Cooperative Oncology Group (ECOG) scale; an estimated life expectancy of >12 weeks; adequate bone marrow function (leukocyte count ≥4000/μL, platelet count ≥100,000/μL, and hemoglobin level ≥9.5 g/dL); adequate hepatic function (bilirubin level ≤1.5 mg/dL and a serum ratio of aspartate amino transferase to alanine amino transferase (AST/ALT) ≤2.5 × UNL); adequate renal function (serum creatinine ≤1.5 mg/dL); a measurable lesion according to the Response Evaluation Criteria in Solid Tumors (RECIST) guidelines version 1.0; and provision of written informed consent. The exclusion criteria were: active infection, massive ascites or pleural effusion, symptomatic brain metastasis, uncontrollable diabetes mellitus, or severe comorbidity such as heart disease or renal disease, interstitial pneumonia, watery diarrhea, active concomitant malignancy, pregnancy or lactation, or other medical problems that could prevent compliance with the protocol. The following conditions were necessary: an interval of at least 4 weeks after the end of final therapy and recovery from the previous treatment.
