*2.1. Material*

All marketed drugs used in this manuscript and the metabolites and the deuterated standards thereof are purchased from commercial providers (Sigma, LKT laboratories, Roche, BD Gentest, Toronto Research, Cerilliant or Syncom). Dabigatran etexilate and its metabolites BIBR 951, BIBR 953, BIBR 1087 and internal research compounds of Boehringer Ingelheim are provided by the internal compound management.
