*2.7. Experimental Animals*

Eight male Sprague-Dawley rats weighing 230–270 g (Orient Bio Inc., Seongnam, Korea) were used in the in vivo studies. The experimental protocols involving animals were reviewed and approved by the Seoul National University Institutional Animal Care and Use Committee, according to the National Institutes of Health Principles of Laboratory Animal Care (publication number 85-23, revised in 1985). The animal protocol number was SNU-180521-4; this protocol was approved on 9 October 2018.
