*2.2. Animals and Rat Liver Microsomes*

Male Sprague-Dawley (SD) rats (12–14 weeks, 200–240 g) were provided by the Experimental Animal Center, Peking University Health Science Center. All animal experimental protocols were approved by the Biomedical Ethical Committee of Peking University Health Science Center (SYXK (Jing) 2016-0041, 23 December 2016). The animal experiments were carried out in accordance with the National Institutes of Health guide for the care and use of laboratory animals (NIH Publications no. 8023, revised 1978).

Pooled SD rat liver microsome (RLM, 20 mg/mL, LM-DS-02M, BDVH) were purchased from the Research Institute for Liver Diseases (Shanghai, China) Co. Ltd.
