Lifestyle Intervention

A lipid lowering diet based on the ESC/EAS guidelines for the managemen<sup>t</sup> of dyslipidemias [8], was proposed to all patients. Lipid intake ranged between 25 and 35% of the daily kcal, with cholesterol lower than 300 mg/day and saturated fats <7% of the total kcal. The protein and carbohydrate intakes were 15–25% and 45–55% of the total daily kcal, respectively. Normal weight and overweight patients were advised to perform moderate-intense exercise at least 30 min per day. The following four different types of diets were administered, in an outpatient setting, after anthropometric and biochemical parameter evaluation:


The compositions of the diets are reported in Supplementary Table S1.

## *2.3. Statistical Analysis*

Statistical analysis was performed using SPSS Statistics 25, Version 25.0 (SPSS Inc., Chicago, IL, USA) (https://www.ibm.com/it-it/analytics/spss-statistics-software, accessed on 31 March 2021). Detailed statistical analysis is reported in the Supplementary Materials.
