**10. Conclusions and Future Prospects**

In present times, there is an increased frequency of resistance for conventional drugs. This fact necessitates the focus of drug research to be shifted toward a new era where bioactive compounds are developed with novel mechanisms of action. TBPs with unique structural features claim their candidature to overcome the existing issues. Various bioactive heteroaromatic peptides have been isolated from different organisms ranging from marine sponges, mollusks, and tunicates to terrestrial cyanobacteria and other microbes including fungi and bacteria. On this basis, various mimetics of bioactive peptides have been synthesized using solid and solution phase techniques of peptide synthesis. Despite enormous potential, utilization of these bioactive peptides is limited due to their stability and bioavailability issues. This review portrays recent updates and future perspectives of TBPs to attract the attention of researchers and scientists leading the efforts toward their clinical translation from the bench to the bedside.

**Author Contributions:** R.D., S.D., N.K.F., J.S. and R.M. conceived and designed the structure of the review. R.D., S.D., S.V.C., A.S., H.G. and A.A. conducted literature research and drafted the entire manuscript. S.D., S.M., S.S., S.F. and S.J. edited the manuscript. R.D., S.D., S.K., G.J., A.K., N.K.F., S.F., S.J. and S.K.K. supervised and contributed to the key parts of the text associated with it. All authors have read and agreed to the published version of the manuscript.

**Funding:** This work was partially funded by the Campus Research and Publication Fund Committee of The University of the West Indies, St. Augustine, Trinidad & Tobago.

**Acknowledgments:** The authors wish to thank chief librarians of Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad & Tobago, WI and University of Puerto Rico, San Juan, PR, USA for providing literature support.

**Conflicts of Interest:** The authors declare no conflict of interest.

#### **References**


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