*3.4. Optical Resolutions of* **1**–**3**

Optical resolutions of agesasine A (**1**) and 9-hydroxydihydrodispacamide (**3**), were performed on chiral HPLC (Chiral ART Cellulose-SB, YMC, φ 4.6 × 250 mm, flow rate 0.5 mL/min, UV detection 254 nm) at 35 ◦C with elution of MeOH/MeCN/H2O/H3PO4 (30:10:60:0.1 for **1**; 8:2:90:0.1 for **3**) to give enantiomers in the integral ratio of ca. 1:1 (*tR* 27.5 and 29.0 min for **1**; *tR* 12.5 and 14.3 min for **3**) in each case. The separations of enantiomers were confirmed by MS analyses. Separated peaks for enantiomers of agesasine B (**2**) could not be obtained in any condition in this study.
