3.1.1. Synthesis of 5-(3-chloropropoxy)-2-hydroxy-acetophenone (**1**)

2,5-Dihydroxyacetophenone (2.0 g, 0.013 mol) was dissolved in dry DMF (13 mL). Then, K2CO<sup>3</sup> (1 eq, 1.8 g, 0.013 mol) and 1-bromo-3-chloropropane (1.1 eq, 1.4 mL, 0.0145 mol) were added. The reaction mixture was stirred under a nitrogen atmosphere heating at 80 ◦C for 4 h. The solution became dark. After cooling, it was diluted with water and extracted with ethyl acetate (three times). The combined organic layers were dried over anhydrous sodium sulfate, filtered and the solvent evaporated under reduced pressure. The obtained dark oil was purified by flash column chromatography in silica gel (hexane: ethyl acetate, 98:2) to produce compound **1** as a light-yellow solid (1.13 g, 0.005 mol). Yield 38%. <sup>1</sup>H-NMR (400 MHz, CDCl3): δ 2.16 (m, 2H), 2.55 (s, 3H), 3.70 (t, 2H), 4.03 (t, 2H), 6.86 (1, 2H), 7.05 (dd, 1H), 7.14 (d, 1H).
