**Pancreatic Diseases and Microbiota: A Literature Review and Future Perspectives**

#### **Marcantonio Gesualdo, Felice Rizzi \*, Silvia Bonetto, Stefano Rizza, Federico Cravero, Giorgio Maria Saracco and Claudio Giovanni De Angelis \***

Gastroenterology and Digestive Endoscopy Unit, AOU Città della Salute e della Scienza, University of Turin, 10126 Turin, Italy; marcantonio.gesualdo@gmail.com (M.G.); silvia.bonetto@edu.unito.it (S.B.); stefanorizza@live.it (S.R.); fed.cravero@gmail.com (F.C.); giorgiomaria.saracco@unito.it (G.M.S.)

**\*** Correspondence: rizzifelice91@libero.it (F.R.); eusdeang@hotmail.com (C.G.D.A.)

Received: 13 October 2020; Accepted: 30 October 2020; Published: 1 November 2020

**Abstract:** Gut microbiota represent an interesting worldwide research area. Several studies confirm that microbiota has a key role in human diseases, both intestinal (such as inflammatory bowel disease, celiac disease, intestinal infectious diseases, irritable bowel syndrome) and extra intestinal disorders (such as autism, multiple sclerosis, rheumatologic diseases). Nowadays, it is possible to manipulate microbiota by administering prebiotics, probiotics or synbiotics, through fecal microbiota transplantation in selected cases. In this scenario, pancreatic disorders might be influenced by gu<sup>t</sup> microbiota and this relationship could be an innovative and inspiring field of research. However, data are still scarce and controversial. Microbiota manipulation could represent an important therapeutic strategy in the pancreatic diseases, in addition to standard therapies. In this review, we analyze current knowledge about correlation between gu<sup>t</sup> microbiota and pancreatic diseases, by discussing on the one hand existing data and on the other hand future possible perspectives.

**Keywords:** pancreatic diseases; microbiota; microbiome; gu<sup>t</sup> microbiota; acute pancreatitis; chronic pancreatitis; diabetes mellitus; pancreatic ductal adenocarcinoma; pancreatic cystic neoplasms
