*Review* **Oral Microbiome and Host Health: Review on Current Advances in Genome-Wide Analysis**

**Young-Dan Cho, Kyoung-Hwa Kim, Yong-Moo Lee, Young Ku and Yang-Jo Seol \***

Department of Periodontology, School of Dentistry and Dental Research Institute, Seoul National University and Seoul National University Dental Hospital, Seoul 03080, Korea; cacodm1@snu.ac.kr (Y.-D.C.); perilab@snu.ac.kr (K.-H.K.); ymlee@snu.ac.kr (Y.-M.L.); guy@snu.ac.kr (Y.K.)

**\*** Correspondence: yjseol@snu.ac.kr; Tel.: +82-2-2072-0308

**Abstract:** The oral microbiome is an important part of the human microbiome. The oral cavity has the second largest microbiota after the intestines, and its open structure creates a special environment. With the development of technology such as next-generation sequencing and bioinformatics, extensive in-depth microbiome studies have become possible. They can also be applied in the clinical field in terms of diagnosis and treatment. Many microbiome studies have been performed on oral and systemic diseases, showing a close association between the two. Understanding the oral microbiome and host interaction is expected to provide future directions to explore the functional and metabolic changes in diseases, and to uncover the molecular mechanisms for drug development and treatment that facilitate personalized medicine. The aim of this review was to provide comprehension regarding research trends in oral microbiome studies and establish the link between oral microbiomes and systemic diseases based on the latest technique of genome-wide analysis.

**Keywords:** oral microbiome; oral disease; systemic disease; genome-wide analysis; personalized medicine
