**4. Impact of DHA on Inflammation Induced by Microglia in Neurodegenerative Diseases: In Vitro and Animal Studies**

Immune activation of the central nervous system is present in neurodegenerative pathologies and involves microglia, major players in neuroinflammation [33]. This inflammatory response, necessary to respond to aggression, can lead to the production of neurotoxic factors when prolonged. It is also characteristic of many neurodegenerative diseases, such as AD, Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and MS [3]. For several years, the anti-inflammatory capacity of DHA or derivatives forms of DHA has been demonstrated.

In the first part, we present the results obtained in vitro (summarized in Table 1) and in the second part, we present the data obtained in vivo with neurodegenerative models (summarized in Table 2).


**Table 2.** In vivo data on the effect of DHA.


**Table 2.** *Cont.*


**Table 2.** *Cont.*
