2.2.2. Cell Morphology

Cell morphology of the control group (Figure 2A) and the morphology of cells treated with 25 μM EGCG (Figure 2B) were spherical, while the morphology of cells treated with 50 ng/mL LPS (Figure 2C) was spindle-shaped. However, the morphology of cells treated with 25 μM EGCG and activated by LPS (Figure 2D) was spherical. This denoted that EGCG can inhibit the activation induced by LPS. Therefore, the pretreatment of EGCG has an inhibitory effect on neuroinflammation, protecting the microglial cells from activation.

**Figure 2.** Morphology of BV-2 cells (**A**) of the control group, (**B**) treated with EGCG, (**C**) treated with LPS, and (**D**) treated with EGCG and then LPS.
