2.2.4. Ponesimod

Ponesimod is a selective S1PR-1 modulator [86,87], with a t1/2 elimination of 21-33 h [87], which like FGM, SPM and OZM, reduces circulating B and T cell lymphocytes by up to 70%, with return to baseline values within 4 days of cessation (see Table 2) [84,88–90], PNM readily crosses the BBB and reduces EAE scores in mice [84].

### **3. Clinical Trial Results**
