3.3.1. Age

There was no significant correlation of serum NfL and age in our cohort (r < 0.3, *p* > 0.05). However, age effects on serum NfL have been described [9,16]. As we mainly compared longitudinal sNfL values from the same individual over a limited period (24 months), no correction for age was made.

### 3.3.2. Serum Cytokine Profile in All Patients

We performed correlation analyses for serum NfL and serum IFN-γ, OPN, IL-2, IL-4 and IL-10 and for all time points. There was no significant correlation between serum NfL and the cytokine profile (r < 0.3, *p* > 0.05).
