*2.1. Population Characteristics*

A total of 69 consecutive Italian patients with ST-elevation myocardial infarction (STEMI) (65 ± 11 years, mean ± SD; 59 males) were enrolled at the Ospedale del Cuore G. Pasquinucci—Clinical Cardiology Department (Massa, a city in *Tuscany*, *which* is a region in *central Italy*) in the period November 2020–May 2021, interspersed with more or less rigid lockdown periods. From January 2021, access to vaccinations was possible, first for healthcare personnel, then progressively for other worker categories (e.g., schoolteachers, etc.). In this time period, lockdown included variable and progressive limitations, which often targeted the restricted territory of the region in which infections were higher, differently from the strict nationwide lockdown during the first wave. In addition, 30 CV subjects afferent to the cardiology outpatient clinic in the period November 2020–May 2021 (62 ± 6 years) and 30 CV outpatients (64 ± 8 years) afferent to the cardiology outpatients clinic of the Ospedale del Cuore G. Pasquinucci during the first COVID-19 wave for the regular periodic check were also evaluated [2].

The definition of STEMI follows the published SC/ACCF/AHA/WHF guidelines for STEMI criteria and management [12].

Standard therapy (e.g., aspirin, beta-blockers, angiotensin-converting enzyme inhibitors, diuretics, statins) was administered to all eligible patients.
