*3.6. LC-HR-MS Analysis*

LC-HR-ESI-MS were acquired using a maXis impact mass spectrometer (Bruker Daltonics, Billerica, MA, USA) coupled to a 1290 Agilent LC (Agilent) using a quadrupole time-of-flight mass detector equipped with an electrospray ionization interface controlled by Bruker software. Column fractions and purified compounds (2 μL) in MeOH were separated on Agilent Eclipse Plus RP-C18 (2.1 × 50 mm; 1.8μm) (Agilent) at 40 ◦C with a flow rate of 0.2 mL/min. The column was eluted with 0.1% formic acid in water (A) and 0.1% formic acid in acetonitrile (B) as follows, 2–95% B for 0–9 min, 95–2%B for 9–11 min, the column was re-equilibrated for 2 min before the next injection. All acquisitions were performed under positive ionization mode with a capillary voltage of 4200 V. Nitrogen was used as nebulizer gas (4.0 bar) and, as well as drying gas at 12 L/min, source temperature was maintained at 250 ◦C. Full scan mass spectra were acquired from *m*/*z* 50–2000. Data processing was done using Data Analysis Version 4.3.
