*4.3. HPLC Analyses of Botanical Sources and BRP*

The chromatographic profiles of BRP samples, and the resins of *D. ecastaphyllum* and *S. globulifera* were obtained by using an HPLC-DAD method on a Waters 1500-series setup (Milford, CT, USA) with an Ascentis Express C18 column (2.7 μm, 150 × 4.60 mm) as the stationary phase and mixtures of water with 0.1% formic acid (B) and acetonitrile (B) as the mobile phase. The flow rate was set at 1.0 mL/min in a gradient elution mode as follows: 20→50% B in 40 min, 50→100% B in 90 min, 100% B (isocratic) until 95 min, 100→20% B until 100 min, 20% B (isocratic) up to 105 min. Benzophenone (20 μg/mL) was used as the internal standard (i.s.). One milligram of each resin sample or propolis extract was dissolved in methanol and subjected to chromatographic analysis. Standard compounds liquiritigenin (**1**), isoliquiritigenin (**2**), formononetin (**3**), vestitol (**4**), neovestitol (**5**), medicarpin (**6**), and 7-O-neovestitol (**7**) were available in the isolated compound library of the laboratory. The standard compounds **1**–**7** and the isolated compounds guttiferone E (**8**) and oblongifolin B (**9**) were dissolved in methanol (20 μg/mL) for HPLC analyses.

**Supplementary Materials:** The 1H and 13C NMR spectra of isolate compounds **8** and **9** are available online.

**Author Contributions:** Conceptualization, G.V.C.-C., J.A.A.M., M.G., J.C.A.S.d.C. and J.K.B.; methodology, G.V.C.-C., J.A.A.M. and J.K.B.; isolation procedures, G.V.C.-C., J.A.A.M. and M.H.T.; resources, J.K.B.; plant identification, M.G.; field research, G.V.C.-C., J.C.A.S.d.C. and J.K.B.; manuscript preparation, G.V.C.-C., J.A.A.M. and J.K.B.; funding acquisition, J.K.B. All authors have read and agreed with the published version of the manuscript.

**Funding:** This research was funded by São Paulo Research Foundation (FAPESP, grants #2017/04138-8, 2017/26252-7, #2018/13700-4 and #2019/01697-1), Coordination for the Improvement of Higher Education Personnel (CAPES) and the National Council for Scientific and Technological Development (CNPq).

**Acknowledgments:** Jairo Kenupp Bastos would like to register that it was an honor to be a student of James D. McChesney, an outstanding scientist and human being.

**Conflicts of Interest:** The authors declare no conflict of interest.
