2.1.3. Field Emission Scanning Electron Microscopy (FESEM)

Nanoscale dimensions were registered for CUR and/or MTX-loaded and non-loaded NCs when their images were assessed by FESEM (Figure 1). NCs were spherically-shaped and had a smooth surface. Their particle size and PDI were similar to those previously recorded [25] by photon correlation spectroscopy. Also, it was found that even after changing CUR and/or MTX concentrations, their morphologies were similar and no drug crystals were seen on their surfaces.

**Figure 1.** Photomicrographs of non-loaded and CUR and MTX-loaded NCs observed by FESEM: (**A**) NCUR/MTX-0 (31,200× magnification) and (**B**) NCUR/MTX-2 (42,500× magnification).
