*4.9. Statistical Analysis*

Prism software (Version 9.0.0, GraphPad, Inc., La Jolla, CA, USA) was used for analysis of all the non-array qPCR and WES data obtained from human tissue and cell culture studies. All values were expressed as mean ± standard error of the mean (SEM). A oneway ANOVA followed by Tukey's post hoc test was used to detect any significant *p*-values. *p* Values less than 0.05 were considered to be significant.

**Supplementary Materials:** The following are available online at https://www.mdpi.com/article/10.3390/ ijms22073492/s1.

**Author Contributions:** Conceptualization, S.B., K.R.W. and N.S.; methodology, S.B., K.R.W. and N.S.; software, S.B., K.R.W.; validation, S.B., K.R.W. and N.S.; formal analysis, S.B. and K.R.W.; investigation, S.B., K.R.W. and N.S.; resources, B.M.; data curation, S.B., K.R.W. and N.S.; writing—original draft preparation, S.B. and K.R.W.; writing—review and editing, S.B., K.R.W., B.M. and N.S.; visualization, S.B., K.R.W. and N.S.; supervision, B.M.; project administration, S.B., K.R.W., B.M. and N.S.; funding acquisition, S.B. and N.S. All authors have read and agreed to the published version of the manuscript.

**Funding:** Funding for S.B. was provided by PhRMA Grant 218218 Pre-Doctoral Fellowship for Pharmacology/Toxicology. NS was partially supported by NCRR/NCATS (NIH) through grant UL1TR000117 (UK-CCTS-Marshall) and NIGMS under grant number P20GM103434 (WV-INBRE).

**Institutional Review Board Statement:** The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Institutional Review Board (or Ethics Committee) of Marshall University School of Medicine (Protocol IRBNET3: 114954-25 and date of approval = 13 May 2020).

**Informed Consent Statement:** Informed consent was obtained from all subjects involved in the study.

**Data Availability Statement:** Data sharing not applicable.

**Acknowledgments:** The authors would like to thank Sandra White and Morgan Ruley for coordinating patient sample collection. The authors would like to thank Robert Nerhood and David Jude (Department of OB-GYN, MUSOM) for their continuous support. We also thank Philippe Georgel for his intellectual contributions to this study.

**Conflicts of Interest:** The authors declare no conflict of interest.
