LXA4 Suppresses MMP Activity, Proliferative Action and Cell Cycle Progression

In experimental models of endometriosis, evidence has shown that LXA4 suppresses the activity of MMPs (MMP-9 and MMP-2) in endometrial lesions via the FPR2/ALX in mice [7,28,29,32]. Treatment with LXA4 in vitro also inhibited the cell cycle's progression in ESCs, consequently attenuating the invasive and proliferative activity associated with endometriotic lesions [19].
