LXA4 Suppresses E2-Induced Epithelial-Mesenchymal Transition

LXA4 suppressed E2-induced EMT of ESCs in vitro, reversing in a dose-dependent manner the reduced expression of epithelial markers (E-cadherin) and the increased expression of mesenchymal markers (Vimentin, N-cadherin and Zinc Finger E-box-binding homeobox 1 (ZEB1)) induced by E2, thus preventing the progress, migration and invasion promoted by endometriosis [7].
