LXA4 Modulates the Expression of Estrogen Receptors

A cross-sectional study of ESCs has shown that treatment with LXA4 and E2 triggered a higher ER-β expression and decreased pro-inflammatory signals. The authors suggest that LXA4 may selectively modulate ER-β in ESCs. In addition, the human endometrium analysis showed a strong positive correlation between the expression of LXA4 and ER-α. In contrast, a negative correlation with ER-β was observed in an in vitro analysis. Further, there was no association between LXA4 and the progesterone receptor (RP). Despite the divergence, it is evident that LXA4 regulates ERs by attenuating E2-induced inflammatory signaling pathways in addition to acting as an E2 receptor agonist [31].
