*4.16. Websites and Software*

The following websites were used for analysis and to download software for this study: http://bioinformatics.sdstate.edu/go/, http://www.gsea-msigdb.org/gsea, https: //www.gencodegenes.org, https://github.com/MikeAxtell/bam2wig, https://www. R-project.org/ (accessed on 25 November 2020).

**Supplementary Materials:** The following are available online at https://www.mdpi.com/article/10 .3390/ijms22168385/s1.

**Author Contributions:** Conceptualization, I.Y. and Q.J.H.; Methodology, I.Y., Q.J.H., F.M.P. and I.H.; Resources, L.K., A.P., H.H. and R.W.; Formal Analysis, I.Y., Q.J.H. and F.M.P.; Data Curation, Q.J.H., F.M.P., K.P., L.K., A.P., H.H. and R.W.; Writing—Original Draft Preparation, I.Y. and Q.J.H.; Writing—Review & Editing, F.M.P., K.P., L.K., A.P., H.H. and R.W.; Visualization, I.Y., Q.J.H., F.M.P. and K.P.; Supervision and Project Administration, I.Y.; Funding Acquisition, H.H. and R.W. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding.

**Institutional Review Board Statement:** The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Institutional Review Board (or Ethics Committee) of Medical University of Vienna (EK 545/2010, approved 9 February 2017).

**Informed Consent Statement:** Informed consent was obtained from all subjects involved in the study.

**Data Availability Statement:** RNA-sequencing data and processed files from this study are available from GEO database under the accession number GSE174741 (https://www.ncbi.nlm.nih.gov/geo/ query/acc.cgi?acc=GSE174741) (accessed on 15 March 2021).

**Acknowledgments:** Open access funding provided by Medical University of Vienna. The authors would like to thank all the participants and health professionals involved in the present study. We want to thank our technical assistants Barbara Widmar and Matthias Witzmann-Stern for their diligent work and constant assistance. We would like to thank Simon Hippenmeyer for access to bioinformatic infrastructure and resources.

**Conflicts of Interest:** The authors declare no conflict of interest.
