*4.15. Statistics*

All statistical tests were performed using SPSS version 27.0 (IBM, SPSS statistics 27.0, Armonk, NY, USA: IBM Corp.) for patient cohort characterization and Prism (GraphPad Prism 9.0 software, La Jolla, CA, USA) for the remaining experimental settings. The exact statistical procedures for each analysis are described in the corresponding figure legends.
