Expression of FPR2/ALX in Endometriosis

According to the literature, in experimental endometriosis, the expression of FPR2/ALX is more significant in the endometrium and uterus than in the ovary. In addition, this expression is increased in the proestral phase (which corresponds to the ovarian follicular phase) and decreased in the estrous phase (corresponding to the ovulatory stage). In parallel, progesterone administration as 17-OH-progesterone also reduced the expression of FPR2/ALX. Furthermore, in both cross-sectional analysis of endometriosis in humans and experimental endometriosis induced in mice, the FPR2/ALX expression was more significant in endometrial lesions than topical endometrium. These data suggest that this receptor is more expressed in women with endometriosis and even more critical in endometriotic lesions, in addition to being regulated by estrogen and progesterone [26].
