Expression of ANXA1 Protein in Endometriosis

Cross-sectional studies have assessed the role of ANXA1 in the pathogenesis of endometriosis in humans. It was shown that its expression is more significant in the endometrium of women with endometriosis [36] and higher in endometriotic lesions (abdominal wall endometrioma). Furthermore, the high levels correlate with morphological changes in this tissue, suggesting that ANXA1 may be involved in cell differentiation and proliferation [38]. However, these data are inconsistent since another study showed a reduced expression of ANXA1 in patients with endometriosis, suggesting that this decrease can facilitate the inflammatory process [39]. In this sense, the lack of studies to better assess the role of ANXA1 and its pathways in endometriosis is evidenced.
