LXA4 Reduces p38 MAPK Phosphorylation, Cytokine Release and COX-2 Expression Induced by Interleukin-1*β* in ESCs via FPR2/ALX

IL-1β is an important pro-inflammatory cytokine that stimulates other cytokines and angiogenic factors. Important to note, LXA4 inhibited IL-1β-induced cytokine release, additionally also inhibited IL-1β-induced p38 MAPK phosphorylation via FPR2/ALX in an in vitro assay [19,35]. Further, LXA4 inhibited COX-2 expression induced by IL-1β in ESCs through the FPR2/ALX modulation. According to Wu et al. in proteomic analysis, LXA4 can suppress proteins that facilitate IL-1β-induced migration and invasion in ESC [34].
