**4. Conclusions**

The pro-resolving mediators of inflammation represent potent endogenous factors, allowing the host tissue to maintain homeostasis and prevent chronic inflammatory diseases. Currently, the treatment of endometriosis includes hormonal and anti-inflammatory therapies. However, these therapies are limited due to the high cost, side effects and recurrence of the disease after discontinuing treatment. Among the mediators, LXA4 is the most studied, acting positively in several aspects related to endometriosis progression and maintenance.

According to the reviewed literature, we believe that there is still a knowledge gap regarding the PRM pathways in patients with endometriosis. It is important to note that these substances' therapeutic potential is evident since the immune response and abnormal inflammatory responses play an essential role in developing, maintaining and progressing this chronic disease.

**Author Contributions:** All authors whose names appear in this article made substantial contributions to the conception and interpretation of data; A.P.P. had the idea for the article, L.K.V. and P.M.P.F. performed the literature search, L.K.V. and C.d.F. performed data analysis. All authors drafted the work or revised it critically for important intellectual content; approved the version to be published; and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding.

**Acknowledgments:** The authors thank the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES) for the partial financing of this study.

**Conflicts of Interest:** The authors have no conflict of interest to declare relevant to this article's content.
