*5.6. Statistical Analysis*

The results are presented as the means ± standard errors of the different mice/group for each experiment and were analyzed using one-way ANOVA followed by Tukey's test. Differences in results were considered statistically significant when *p* < 0.05.

**Author Contributions:** Conceptualization: B.C.Z., P.B.C., L.R.C.G.; Investigation: B.C.Z., P.B.C., E.C., E.L.F.-M., A.S.A.; Resources: A.S.A., C.B.; Supervision and Funding acquisition: L.R.C.G.; Writing original draft: B.C.Z., P.B.C., L.R.C.G.; Writing revision/editing: B.C.Z., P.B.C., E.C., A.S.A., C.B., E.L.F.-M., L.R.C.G. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research was funded by Fundação Butantan and Fundação de Amparo à Pesquisa do Estado de São Paulo—FAPESP (grant n◦ 2008/00108-8 and 2010/09002-8), and LRCG and ELFM were research fellows of Conselho Nacional de Desenvolvimento Científico e Tecnológico—CNPq (process 308083/2013-0, 309392/2015-2, and 312096/2018-6).

**Institutional Review Board Statement:** All experimental procedures were conducted according to the ethical parameters proposed by the International Society of Toxinology and the Brazilian College of Experimental Animals and were approved by the Ethical Committee for the Use of Animals of Butantan Institute (n◦ 466/08), approval date (09/04/2008).

**Informed Consent Statement:** Not applicable.

**Data Availability Statement:** The data presented in this study are available on request from the corresponding authors.

**Acknowledgments:** The authors also thank Luiz R. G. Britto for assistance with his laboratory facilities and for providing helpful suggestions.

**Conflicts of Interest:** The authors have no conflict of interest regarding this work to declare.

#### **References**

