**4. Conclusions**

Gathering computational and experimental results, we were able to characterize a novel anti-hemostatic serpin, Dromaserpin, from the salivary glands of *H. dromedarii*. We believe that this is the first recombinant serpin identified from the *Hyalomma* genus which inhibits thrombin in both blood coagulation and platelet aggregation. We also suggested an inhibition mechanism implicating heparin as a cofactor. Future research will explore its molecular mechanisms and kinetics as an anticoagulant candidate. Besides, its effectiveness must be verified in vivo to testify its feasibility as a potential of medicinal applications mainly in treatment of blood clotting disorders.
