*5.1. Crotoxin*

CTX was obtained from the venom collected from several *Crotalus durissus terrificus* and provided by the Laboratory of Herpetology, Butantan Institute. The purification of this toxin was performed as described previously [58]. The purity of CTX was verified by non-reducing sodium dodecyl sulfate-polyacrylamide gel electrophoresis (12.5%) [59] and PLA2 activity was assessed by colorimetric assay using a synthetic chromogenic substrate as described elsewhere [60].
