*3.1. General Experimental Procedures*

Analytical separations were performed on a Waters ACQUITY UPLC instrument employing a UPLC Kinetex C18 column (1.7 μm, 2.1 × 50 mm, Phenomenex) and an HPLC Kinetex C18 column (5 μm, 5 × 250 mm, Phenomenex), respectively, combined with a Waters 2998 photodiode array detector (PDA) (Waters, Milford, MA, USA). Medium pressure liquid chromatography (MPLC) was carried out on a Biotage-Isolera One system (SE-751 03 Uppsala, Sweden) equipped with a YMC-Pack ODS-A column (500 mm × 50 mm, 50 μm, YMC, Tokyo, Japan). All LC/MS data were obtained on a Phenomenex Kinetex C18 analytical column (1.7 μm, 2.1 × 50 mm, Phenomenex) using an Agilent HPLC equipped with a Bruker Maxis impact QTOF system mass spectrometer. Chromatographic analyses for configuration analysis were performed using an HPLC system consisting of a pump (model PU-2080, JASCO, Easton, MD, USA) and a UV detector (model UV-2075, JASCO). The NMR data were recorded using standard pulse programs on a Bruker AVANCE NEO 600 spectrometer equipped with a 5 mm inverse detection triple resonance (H-P/C/N-D) QCI 600S3 cryoprobe, capable of applying z-gradients. The chemical shifts were calibrated relative to the residual solvent peak in DMSO-*d*<sup>6</sup> (*δ*<sup>H</sup> 2.50 and *δ*<sup>C</sup> 39.52). High-resolution electrospray ionization mass spectra (HRESIMS) were measured on an Agilent (Santa Clara, CA, USA) 6545 Q-TOF instrument. Optical rotations were measured with a JASCO P-2000 automatic polarimeter.
