*4.3. Genome Mining for Antimicrobial Compounds*

Putative biosynthetic gene clusters (BGCs) were predicted using *anti*SMASH (antibiotics and Secondary Metabolite Analysis Shell 5.0) [57] and Bagel4 (bacteriocins and RiPP—Ribosomally synthesized and Post-translationally modified Peptides) [58] using the default parameters. The bacteriocin classification is in accordance with previous proposals for enterococci [33] and lactic acid bacteria [36] that accommodate the novel subclasses that are appearing over the last years, based on the biosynthesis mechanism and biological activity.
