*2.5. PVA-Based Carrier and Drug Release Study*

The dissolution tests were performed using a Hanson SR-8 Plus™ Dissolution Test Station (Hanson Research, Los Angeles, CA, USA) with the paddle (USP 30 dissolution apparatus II) method at a rotation speed of 50 rpm, in 37 ± 0.2 ◦C medium of 500 mL volume. At predetermined time-points, 5 mL of samples were withdrawn and filtered through 10 μm pore size membrane full-flow filters from the media by Hanson® AutoPlus Multifill collector (Hanson Research, Los Angeles, CA, USA). After every sampling, media replacement was accomplished with 5 mL of fresh buffer solution. The dissolution tests were performed in triplicates in the instance of every samples.
