**5. Conclusions**

SARS-CoV-2 vaccines are highly effective in reducing the number of COVID-19- related deaths in over 75 year-olds in Brazil, one of the hardest hit countries by the current pandemic.

**Author Contributions:** Conceptualization, C.H.A., L.P.G.C. and J.H.; methodology, C.H.A. and J.H.; formal analysis, C.H.A.; writing—original draft preparation, C.H.A., L.P.G.C. and J.H.; writing— review and editing, C.H.A., L.P.G.C., M.M.A., P.P.L.B., K.K.S.C., D.N.M., B.C.F.B.A. and J.H. All authors have read and agreed to the published version of the manuscript. C.H.A., L.P.G.C. and J.H. contributed equally.

**Funding:** This research did not receive external funding.

**Informed Consent Statement:** Patient consent was waived due to the research being conducted with secondary data from the immunization and mortality information systems. We obtained a declaration from the Ethical Review Board of the Federal University of Ceará (Fortaleza, Brazil) exempting us from the need for ethical clearance for this study. This exemption from ethical clearance is based on Brazilian laws: Law No. 12,527 of 18 November 2011 and National Health Council (CNS) Resolution No. 510 of 7 April 2016.

**Data Availability Statement:** The data presented in this study are publicly available in: https:// integrasus.saude.ce.gov.br/#/indicadores/indicadores-coronavirus/indice-transparencia (accessed on 13 July 2021).

**Acknowledgments:** L.P.G.C. and J.H. are research fellows at the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq/Brazil).

**Conflicts of Interest:** The authors declare no conflict of interest.
