**Appendix A**

**Figure A1.** 3D visualization of conserved residues (lines) in the prothrombin ligand (sticks) binding process (PDB ids 1t4u in pink, 1z71 in blue and 3u9a in orange). **References Figure A1.** 3D visualization of conserved residues (lines) in the prothrombin ligand (sticks) binding process (PDB ids 1t4u in pink, 1z71 in blue and 3u9a in orange).
