**5. Conclusions**

In conclusion, it is proposed that the genotype and phenotype correspond to Ayurvedic Janma (birth) Prakriti and Deha (body) Prakriti (psychophysiological constitution), respectively. Imbalance or disorder of the Deha Prakriti is known as Vikriti and corresponds to disorders and diseases in the current medical system. It is proposed that mRNA, tRNA, and protein have features and properties that represent the three governing principles of the physiology or Ayurvedic doshas—Vata, Pitta, and Kapha—at the cellular level. There are four major factors that a ffect the phenotype or Deha Prakriti in a positive or negative way, depending on what one does in one's life. These four factors are lifestyle and behavior, diet and digestion, stress, and environmental factors. These factors produce changes in the phenotype or Deha Prakriti that a ffect the expression of the genotype, the Janma (birth) Prakriti, without changing its basic structure. Ayurveda addresses these four major factors of life and thereby a ffects both the phenotype and genotype in a positive way through the process of epigenetics. Thus, it is proposed that epigenetics is an important mechanism of Ayurveda. This correlation and understanding of the process of healing and health maintenance will improve the understanding and communication between Ayurveda and the current medical system, and lead to better integration of both sciences in the managemen<sup>t</sup> of optimal health. In addition, research on Ayurvedic modalities affecting gene expression will further increase the correlation and understanding between the current medical system and Ayurveda.

**Funding:** A gran<sup>t</sup> from the Wege Foundation provided for publication costs. **ConflictsofInterest:**Theauthorsdeclarenoconflictofinterest.
