*Review* **Enzymatic Bioreactors: An Electrochemical Perspective**

#### **Simin Arshi 1 , Mehran Nozari-Asbemarz <sup>2</sup> and Edmond Magner 1, \***


Received: 30 September 2020; Accepted: 18 October 2020; Published: 24 October 2020

**Abstract:** Biocatalysts provide a number of advantages such as high selectivity, the ability to operate under mild reaction conditions and availability from renewable resources that are of interest in the development of bioreactors for applications in the pharmaceutical and other sectors. The use of oxidoreductases in biocatalytic reactors is primarily focused on the use of NAD(P)-dependent enzymes, with the recycling of the cofactor occurring via an additional enzymatic system. The use of electrochemically based systems has been limited. This review focuses on the development of electrochemically based biocatalytic reactors. The mechanisms of mediated and direct electron transfer together with methods of immobilising enzymes are briefly reviewed. The use of electrochemically based batch and flow reactors is reviewed in detail with a focus on recent developments in the use of high surface area electrodes, enzyme engineering and enzyme cascades. A future perspective on electrochemically based bioreactors is presented.

**Keywords:** bioelectrocatalysts; oxidoreductases; biocatalytic reactors; electrochemical reactors
