Reprint

Update on the Management of Non-Obstructive Azoospermia: Current Evidence and Unmet Needs

Edited by
March 2022
168 pages
  • ISBN978-3-0365-3433-6 (Hardback)
  • ISBN978-3-0365-3434-3 (PDF)

This book is a reprint of the Special Issue Update on the Management of Non-Obstructive Azoospermia: Current Evidence and Unmet Needs that was published in

Medicine & Pharmacology
Public Health & Healthcare
Summary

Azoospermia, defined as the absence of sperm in the ejaculate after examination of the centrifuged specimens, affects about 1% of the male population and 10–15% of infertile men. In about two-thirds of cases, this is caused by severe spermatogenic dysfunction, and it is commonly termed “nonobstructive azoospermia” (NOA) to differentiate it from the less severe form of azoospermia caused by the obstruction of the seminal tract (obstructive azoospermia—OA), the latter affecting the remaining one-third of cases. Managing patients with NOA is challenging due to the severity of spermatogenic dysfunction and the lack of medical treatments, with surgical retrieval of testicular sperm being the only way of enabling some of these patients to father their own biological children. In-depth clinical knowledge is key for supporting clinical reasoning and decision making when counselling patients with NOA, and surgical skill is required to maximize the outcome of surgical procedures that aim to retrieve testicular sperm.

The present book is a collection of scientific papers published in a Special Issue of the Journal of Clinical Medicine, authored by some of the most influential researchers in the field. The Special Issue, and thus also this book, were conceived to provide early career reproductive urologists and endocrinologists with an update of the scientific evidence in the field, together with surgical tips.

Format
  • Hardback
License
© by the authors
Keywords
nonobstructive azoospermia; micro-TESE; FSH treatment; hormonal treatment; testosterone level; microdissection testicular sperm extraction; non-obstructive azoospermia; management; non-obstructive azoospermia; infertility; intracytoplasmic sperm injection; testicular azoospermia; non-obstructive azoospermia; sperm selection; sperm; cryopreservation; in vitro maturation; azoospermia; diagnosis; male infertility; nonobstructive azoospermia; spermatogenic failure; testis biopsy; sperm retrieval; genetic testing; endocrine evaluation; review; hypogonadism; intracytoplasmic sperm injection; Sertoli cell-only syndrome; non-obstructive azoospermia; testicular spermatozoa; processing; microfluidics; new technologies; azoospermia; infertility; genetics; exome; WES; Y chromosome; cancer; NOA; genes; general health; ICSI; offspring health; microTESE; sperm retrieval; non-obstructive azoospermia; male infertility; non-obstructive azoospermia; sperm retrieval; male infertility; microTESE; prediction model; n/a