Brain Levels of Serotonin

França et al. [56] measured the effects of caffeine consumption and physical exercise throughout adolescence on serotonin (5-hydroxytryptamine, 5-HT) through highperformance liquid chromatography (HPLC). A statistical analysis performed by the authors showed that the combination of caffeine consumption and physical exercise during adolescence increased 5-HT levels in the prefrontal cortex of SHRs. Concerning hippocampal 5-HT levels, statistical comparisons showed that caffeine consumption and physical exercise, alone or in combination, significantly augmented hippocampal 5-HT levels.
