3.1.2. Animal Models of ADHD

Overall, nine studies used genetic animal models of ADHD: eight studies used SHR, and one study used the low-density lipoprotein receptor (LDLr) mouse. Finally, two studies used physical trauma to provide an epigenetic animal model of ADHD: one study caused 6-hydroxy-dopamine (6-OHDA) lesions in rats, while one study used social isolation (SI) as an intensely stressful environment in mice (Table 1).
