**5. Conclusions**

Plant-derived bioactive compounds or mixtures have gradually become a hot topic in recent years, as a growing body of data points to their beneficial effects. However, these effects can vary from cell type to cell type. Here, we showed that, although sea-buckthorn seed oil has been associated with skin health and protection against irradiation, it also stimulates proliferation of dysplastic cells, while impairing the ability of both normal and dysplastic cells for wound-healing. We also investigated the expression of CD36, a fatty acid translocator, on normal and dysplastic keratinocytes, and we found that UVA exposure increases its expression, which could hold functional significance for further progression towards malignancy.

**Supplementary Materials:** The following are available online at https://www.mdpi.com/article/10 .3390/jpm11040278/s1, Table S1: Optimized parameters for fatty acids mass spectrometric detection.

**Author Contributions:** M.D., A.C.V., E.C., I.D.P., S.M., L.A. and I.T. performed cell culture-based experiments; I.T. and G.M. performed chromatographic and mass-spectrometry analysis; L.C.C. performed confocal microscopy data acquisition, interpretation and report; A.-M.E. designed the study; A.-M.E., C.T. and M.E.H. designed the study and critically read the manuscript; A.-M.E., M.D. and A.C.V. wrote the manuscript; A.-M.E. was the project Administrator; C.T. was responsible for funding acquisition. All authors have read and agreed to the published version of the manuscript.

**Funding:** This work was partially funded by Ministry of Research and Innovation grant: COP A 1.2.3., ID:P\_40\_197/2016 and PN 19.29.01.04.

**Acknowledgments:** The graphical abstract was created with BioRender.com.

**Conflicts of Interest:** The authors have no conflict of interest to declare.
