**2. Materials and Methods**

This study was conducted in accordance with the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions (v. 6.2) [21] and reported based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement [22]. The methodology was prespecified and registered on the PROSPERO website (Registration No. CRD42020173098). Two reviewers (H.R. Tsai and J.W. Lu) independently searched for suitable records, extracted the data, and evaluated the quality of the included studies. In the event of any discrepancy, a third reviewer (T.L. Chen) provided consensus or contributed to the discussions.
