**1. Introduction**

*Leukoderma acquisitum centrifugum*, later known as *Sutton nevus* or *halo nevus*, appeared in 1916 in the writings of Richard Lightburn Sutton [1,2]. The recognition of Dr. Richard Lightburn Sutton's work from whom the clinical entity takes its name has its root in describing and observing for the first time the disease in two of his patients [1,2]. Sutton described two cases of peculiar brown maculo-papules, but he considered the lesions to be clinical variants of vitiligo. He introduced his cases of abnormal pigmentation with a review of the cellular origins of pigmentation and vitiligo. It was only later that John H. Stokes made the correlation of *leukoderma acquisitum centrifugum* with melanocytic nevi [3].

**Citation:** Nedelcu, R.; Dobre, A.; Brinzea, A.; Hulea, I.; Andrei, R.; Zurac, S.; Balaban, M.; Antohe, M.; Manea, L.; Calinescu, A.; et al. Current Challenges in Deciphering Sutton Nevi—Literature Review and Personal Experience. *J. Pers. Med.* **2021**, *11*, 904. https://doi.org/ 10.3390/jpm11090904

Academic Editors: Mircea Tampa, Monica Neagu, Constantin Caruntu, Simona Roxana Georgescu and Reginald M. Gorczynski

Received: 22 July 2021 Accepted: 6 September 2021 Published: 9 September 2021

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With no gender or racial predilection, Sutton nevi are found in approximately 1% of young adults. The mean age at onset is thought to be 15 years. It is unusual and a sign of suspicion if a depigmentation around a nevus is found in an older patient [4,5].

The most common sites for Sutton nevi are the back, followed by head and neck [6,7]. The halo phenomenon can develop around preexisting junctional or compound nevi. [8].

Attempts have been made to better understand the natural evolution of halo nevi, by describing and didactically dividing the disease into four stages [8,9]: Stage I corresponds to the presence of the characteristic depigmented rim around the nevus; Stage II, with loss of pigment within the central nevus surrounded by a depigmented rim; Stage III is described by the presence of a circular area of depigmentation with the total disappearance of the nevus; Stage IV corresponds to the repigmentation phase, with normal appearing skin. The changes can develop for over 10 years.
