3.4.4. Subgroup Analyses and Meta-Regression of Efficacy Outcomes

The subgroup analyses indicated that JAK inhibitors improved AD. From the metaregression analyses, we identified age as a potential effect modifier of EASI-75 responses. Studies involving children and adolescents showed a higher RR of achieving an EASI-75 response than those exclusively involving adults (Table S2). According to the subgroup analyses of different JAK inhibitors at different time points, gusacitinib was unlikely to achieve EASI-75 and IGA responses (Table S3).
