*2.2. Animal Model*

C57 BL/6 mice (Jackson Laboratory, Bar Harbor, ME), males and females, aged 10–11 weeks, were provided by the Animal Husbandry from Victor Babes, National Institute of Pathology. The animals were kept in an open cage system, in optimal conditions (temperature 22 ± 2 ◦C, humidity 55 ± 10%, artificial ventilation, 12/12-light/dark cycle) and fed (standard granulated fodder) and watered (filtered and sterilized water) *ad libitum*. The mice were monitored daily. The experiments were conducted in accordance with recognized principles of laboratory animal care in the framework of EU Directive 2010/63/EU [45] and the study was comprised in a research project that was approved by the Ethics Committee from Victor Babes, Institute (Approval no 88/20 January 2021) and National Sanitary Veterinary and Food Safety Authority (Approval no 598/8 February 2021).

The experimental murine model of psoriatic dermatitis was performed according to the protocols previously described [43,44,47].

Four groups of C57 BL/6 mice, were constituted as follows:

