**5. Parvovirus-Based Combinatorial Immunotherapy against Melanoma**

Cutaneous melanoma, also known as black skin cancer, is an aggressive tumor arising from the melanocytes. Over the past 10 years, melanoma has become a prototype for testing novel targeted therapies, first and foremost, immune checkpoint blockade. PD-1 inhibition has shown significant clinical success in controlling locoregional melanoma [71]. However, metastatic melanoma is a severe life-threatening condition for which reinforcement of current treatment tools and approaches is still needed.
