*3.3. M032*

M032 is derived from the HSV-1 F-strain, containing deletions for both alleles of the neurovirulence factor γ*34.5* and armed to express the stimulatory cytokine IL-12 [51,52]. The murine variant of this construct–M002–has been well characterized by Parker et al. [53]: In vitro data support its toxicity against human glioblastoma and murine neuroblastoma cell lines, and in vivo survival data from neuroblastoma-bearing mice indicate a significant increase of median survival compared to control; immunohistologic workups of murine brain sections revealed an increase of CD4+- and CD8+-T-cells. A phase-1 trial (NCT02062827) is investigating safety and tolerability of M032 in patients with recurrent or progressive high-grade glioma.
