**2. Strategies towards Cancer-Specific and Efficacious oHSVs**

In recent years efforts were made to generate cancer-specific rather than cancerselective oHSVs. Such viruses gain safety from specificity, contain the entire set of viral genes so that they counteract the antiviral innate response, replicate robustly in the tumor cells, and are effective in releasing the immune suppression typical of cancers and in reactivating tumor recognition by the immune system.
