*2.3. Affiliation of Collecting Significant Data*

The electronic PUB MED database from the last 2 years was accessed using the keywords referring to the periods of home confinement imposed by SARS-CoV-2 outbreak. Articles were searched that referred to neurodegenerative diseases with motor and cognitive disorders; strategies for wellbeing of physical and mental life as well as remote rehabilitation through stimulating physical activities to increase the quality of life.

In this sense, 65 of the most representative papers from the PUB MED electronic database were selected. The papers focused on received interventions at home during the restrictions imposed by the COVID-19 pandemic, through online digital platforms or semistructured interviews, regarding physical exercise programs, development daily household activities, online interviews regarding physical and mental state of the participants or eating habits approached during this period. After the elimination of duplicate papers, 64 studies remained to be scanned, and of these, another 16 papers that did not refer to neurodegenerative diseases were eliminated. Of the 48 full-text clinical trials and articles assessed for eligibility, 30 were excluded for the following reasons: 12 studies were systematic reviews, 1 paper was a case study, 6 papers were abstract studies, 7 studies

were not free to access and 4 papers did not refer to physical activity. Thus, in the end, only 18 studies that addressed healthy adults and patients with: Parkinson's disease, Alzheimer's disease, Lewy body disease, Frontotemporal dementia and associated diseases (Vascular dementia, Myasthenia gravis), will be discussed for qualitative synthesis.
