*Article* **Impact on the Mental and Physical Health of the Portuguese Population during the COVID-19 Confinement**

**Fátima Frade 1,2, Lia Jacobsohn 3,4, Juan Gómez-Salgado 5,6,\*, Rosário Martins 7, Regina Allande-Cussó 8, Carlos Ruiz-Frutos 5,6,† and João Frade 9,10,†**


**Abstract:** Confinement of the population has been one of the measures implemented by different governments to address the COVID-19 health crisis, and it has led to social isolation together with a disruption of daily activities. The aim of the study is to analyze psychological distress during the COVID-19 pandemic in Portugal. During the quarantine, a cross-sectional study was carried out on a sample of 2120 subjects over 18 years of age, resident and born in Portugal. Data were collected using a self-developed questionnaire that considered socio-demographic variables, physical symptoms, health conditions, and history of contact with COVID-19, as well as psychological alterations. The General Health Questionnaire (GHQ-12) was also included. Univariate and bivariate statistical analyses were performed. Predictive capacity was studied using logistic regression models. The results showed a higher percentage of individuals presenting psychological distress (57.2.0%), with a higher percentage identified among women (79.0%), and in people with a higher educational level (bachelor's + master's and doctorate) (75.8%). The predictor variables with the greatest weight were sex, educational level (graduation, master's, and doctorate), living with children or under 16 years of age, presence of symptoms, and quarantine in the last 14 days for having symptoms. Good self-assessment of health and working at home appear to be protective against psychological distress. These results highlight the impact of the COVID-19 pandemic on psychological distress and provide an opportunity to consider the need to implement specific multidisciplinary public health and mental health interventions in this pandemic situation.

**Keywords:** COVID-19; psychological distress; pandemic; public health; quarantine; mental health
