*2.4. Quality Assessment*

Methodological quality in all studies was assessed using the Crowe Critical Appraisal Tool (or CCAT; [12,13]). Since several study designs were eligible, it was important to use a quality assessment tool designed for a broad range of study designs. The CCAT was developed to assess methodological quality of randomized controlled trials as well as other study designs and was, therefore, suitable for the current study. We shall interpret CCAT scores in quintiles to categorize studies as very low (0–8 points), low (9–16 points), moderate (17–24 points), high (25–32 points) or very high (33–40 points) methodological quality similar to [14]. The current review reports both the section scores per paper as well as the total scores overall, which are needed to draw conclusions both on an individual paper level, as well as for the entire field.
