**logit P** = 4.92 − 0.094 × *LSNS-6* + 1.753 × *COPD* − 0.553 × *MNA*

During the interviews, patients were also asked if wearing masks makes them feel uncomfortable. Thus, the difficulty of wearing masks was observed among 174 (34.8%) patients, mainly in those suffering from asthma (*p* < 0.001, Figure 3A, Table S3), COPD (*p* = 0.008, Table S3), and heart failure (*p* < 0.001, Table S3). Moreover, it occurred significantly more often in participants who are afraid of vaccination because of potential side effects (*p* < 0.001, Figure 3B, Table S3), those willing to be vaccinated against influenza but could not undergo vaccination due to the lack of vaccines in pharmacies (*p* = 0.013, Table S3) and those who take cardiac drugs (*p* = 0.042, Table S3) and analgesics (*p* = 0.019, Table S3). Moreover, difficulties with wearing masks and/or gloves were significantly more often observed in patients assessing more complex daily activities (*p* = 0.005, Figure 3C, Table S3), with depression according to GDS-15 (*p* < 0.001, Figure 3D, Table S3), with a higher level of anxiety according to GAS-10 (*p* < 0.001, Table S3), and with a higher level of social loneliness according to LSNS-6 (*p* = 0.001, Figure 3E, Table S3).

**Figure 3.** (**A**) Number (*n*) and percentage (%) of patients for whom wearing a mask and/or gloves is a great difficulty, differing in those suffering from asthma and healthy patients; (**B**) Number (*n*) and percentage (%) of patients avoiding vaccination due to potential side effects for whom wearing a mask and/or gloves is a great difficulty; responses/answers to the question regarding possible difficulties of wearing masks and/or gloves in less fit (**C**), depressed (**D**) and feeling lonely (**E**) patients and the number of independent, non-parametric, significance tests.

> For instance, the chance of an affirmative answer to the question about the difficulty of wearing a mask and/or gloves in the group of people with asthma is almost three times higher in healthy patients (OR = 2.79, 95% CI [1.40–5.54]) and two times higher in those avoiding vaccinations due to potential side effects (OR = 2.00, 95% CI [1.33–2.99]). Difficulties with wearing a mask and/or gloves were also 0.91 times more common in patients assessing more complex activities (OR = 0.91, 95% CI [0.84–0.99]), 1.07 times more common in depressed patients (OR = 1.07, 95%CI [1.02–1.13]), and 0.86 more common in feeling lonely patients (OR = 0.86, 95%CI [0.77–0.96]) than physically and mentally healthy people. Detailed data on analyzing those having difficulties with wearing masks or gloves during the COVID-19 pandemic are presented in Table 5.

**Table 5.** Results of univariate and multivariate logistic regression of the answer to the question regarding difficulties with wearing a mask and/or gloves in elderly patients and socio-demographic and clinical factors as well as the odds ratio [OR] and its 95% confidence interval [CI] [the most statistically significant (*p*-value < 0.05) predictors of feeling difficulties in wearing a mask and/or gloves in elderly patients during COVID-19 pandemic].


*b*—linear regression coefficient, β—standardized multiple regression coefficients.

The generalized logit regression model leading to estimate the probability of an affirmative answer to the question is it difficult to wear a mask and/or gloves, by elderly patients took the form:

**logit P** = 2.72 + 1.025 × *asthma* − 0.091 × *IADL* − 0.15 × *LSNS-6* + 0.692 × *avoiding vaccination* + 0.071 × *GDS-15*

#### **4. Discussion**
