*3.1. Evaluation of Mean Scores on Generalized Anxiety Disorder (GAD-7), Patient Health Questionnaire (PHQ-9), and Insomnia Severity Index (ISI) Scales*

Female subjects significantly more often presented symptoms of anxiety, depression and insomnia. Differences in mean scores on GAD-7 (*p* = 0.004), PHQ-9 (*p* = 0.013) and ISI (*p* = 0.006) were observed between patients with and without hypertension. Moreover, statistically significant differences in mean GAD-7, PHQ-9 and ISI scores were found between smoking and non-smoking patients (*p* < 0.001) and between patients with and without Hashimoto (*p* < 0.001). In addition, significant differences were found between patients with and without dyslipidemia in mean ISI scores (*p* = 0.035). The mean GAD-7, PHQ-9, and ISI scores are presented in Table 1.


**Table 1.** Mean GAD-7, PHQ-9, and ISI scores for selected parameters.

Abbreviations: *p*–statistical significance; Me–median; SD–standard deviation; GAD-7–Generalized Anxiety Disorder scale; PHQ-9–Patient Health Questionnaire; ISI–Insomnia Severity Index.

#### *3.2. Analysis of Correlation between Selected Parameters and GAD-7, PHQ-9, and ISI Scores*

The correlation analysis showed a strong correlation between the occurrence of Hashimoto's disease and an increase in ISI score (r = 0.797, *p* < 0.001), GAD-7 scale (r = 0.766, *p* < 0.001) and PHQ-9 scale (r = 0.767, *p* < 0.001). A case comparison is presented in Table 2. Therefore, for further analysis, only Hashimoto's disease was included as a predictor of insomnia, anxiety, or depression.

**Table 2.** Analysis of correlations between selected parameters and GAD-7, PHQ-9, and ISI scores.


Abbreviations: *p*–statistical significance; R–correlation coefficient; GAD-7–Generalized Anxiety Disorder scale; PHQ-9–Patient Health Questionnaire; ISI–Insomnia Severity Index.

### *3.3. Evaluation of Selected Parameters Depending on the Occurrence of Hashimoto's Disease*

The analysis of the selected parameters depending showed statistically significant differences in gender (*p* < 0.001), age (*p* < 0.001), hypertension (*p* < 0.001), dyslipidemia (*p* = 0.004) and smoking cigarettes (*p* < 0.001) between participants with and without Hashimoto. The results are presented in Table 3.


**Table 3.** Evaluation of selected parameters depending on the occurrence of Hashimoto's disease.

Abbreviations: *p*—statistical significance; *n*—number of patients; % percentage of patients.
