**Agata Fiumara 1,\*, Giuseppina Lanzafame 1, Alessia Arena 1, Annamaria Sapuppo 1, Federica Raudino 1, Andrea Praticò 1, Piero Pavone <sup>1</sup> and Rita Barone <sup>2</sup>**


Received: 6 August 2020; Accepted: 19 August 2020; Published: 22 August 2020

**Abstract:** Background: Lysosomal storage disorders (LSDs) are rare, chronic, progressive multisystem diseases implying severe medical issues and psychological burden. Some of these disorders are susceptible to a treatment, which is administered weekly or every other week, in a hospital. During the COVID-19 (Corona Virus Disease 2019) pandemic lockdown, patients with LSDs on enzyme replacement therapy (ERT) missed their scheduled access to the Day Hospital to get their treatment. Methods: Based on the feeling that our patients were experiencing profound distress, we designed a structured telephone interview with the aim to evaluate how, and to which extent, the pandemic outbreak was changing their behavior and feelings about their chronic disease, the impact on therapies, and future expectations. The same interview was administered to an age-matched control group. Results: All interviewed people experienced an increase of anxiety, worries, and uncertainty fostered by incessant media updates. Moreover, a striking similarity emerged between the groups regarding forced home reclusion and the profound feeling to be excluded by normal life, well-known to those affected by a chronic rare disease. Conclusions: Although no statistically significant difference was found compared to controls, we felt that the reactions were qualitatively different, underlining the fragility and isolation of such patients.

**Keywords:** COVID-19 pandemic; ERT; lysosomal storage disease; psychological impact
