*3.1. Cardiovascular and Pre-Frailty Risk Assessment (CFRA)*

We developed a 4-point Cardiovascular and Pre-Frailty Risk Assessment (CFRA) method that provides a quantitative method for assessment of the cardiovascular and pre-frailty risk. We chose the following biomarkers: daily steps, resting heart rate, sleep duration, and age. The more points scored, the higher probability of developing cardiovascular health outcomes and frailty syndrome. The Cardiovascular and Pre-Frailty Risk Assessment 4-point method was exhibited in Table 1.


**Table 1.** Cardiovascular and Pre-Frailty Risk Assessment method.

**Table legend:** bpm—beats per minute.
