*2.3. Ethical Statement*

The study was approved by the Bioethics Committee of the Nicolaus Copernicus University in Torun at Collegium Medicum of Ludwik Rydygier in Bydgoszcz, Poland (approval no. 437/2020). The study was conducted according to the Declaration of Helsinki regarding research on humans. All subjects provided informed consent to participate in the study.
