**4. Cell, Plant, and Animal Models**

Phylogenetic analysis of peroxisomal ABC transporters in eukaryotes shows strong conservation, highlighting their fundamental and specific role in the cellular functions. Interestingly, their substrate specificity seems to become more restrictive with the complexification of the biological systems. Although the number of peroxisomal ABC transporters and their specific functions vary between species, each model of study is of scientific interest and has contributed significantly to the knowledge of peroxisomal ABC transporters. Here are described the main eukaryote models.
