*8.3. Human Cytomegalovirus (HCMV) and Other Viruses*

HCMV is an opportunistic pathogen associated with an increased risk of atherothrombosis. In vitro models demonstrated that HCMV infection and the viral US28 protein decrease ABCA1 expression in the host cell, altering the distribution of lipid-rich microdomains in the plasma membrane [229,260]. Finally, although cholesterol metabolism has been found to be altered in other viral infections such as dengue [261,262] and chikungunya [263], the direct participation of ABCA1 in these diseases has not been demonstrated [261,263,264].
