*2.1. Pseudoxanthoma Elasticum*

Pseudoxanthoma elasticum (PXE) is a rare disorder with progressive ocular, vascular and skin abnormalities that result from the accumulation of morphologically abnormal calcified elastic fibers [25]. The skin manifestations are the most prevailing characteristic of PXE, but the ocular and cardiovascular symptoms are responsible for the morbidity of the disease.

The first description of the clinical signs of PXE appeared in the literature more than a century ago [26–28]. Is it Darier who proposed the term "pseudoxanthome élastique", which remains largely used to this day as pseudoxanthoma elasticum [29].
