*2.7. ABCA6*

The human *ABCA6* gene has no known orthologs in Sauropsida (reptiles and birds) and ray-finned fishes. The transcript ABCA6-201 is 5321 bp long and has 39 exons. The 5′UTR is 196 nt long and divided into two parts by Intron 1–2 (996 bp). The most conserved sub-region is located to −156 to −63. Two uATGs were found within the region (−144 and −32). The first uATG is conserved within placental mammals (cat. 3) and shows an adequate context and middle TIS score; the second is conserved only in primates (cat. 1) and has also an adequate context, but low TIS score. Notably, the sATG of this transcript shows only a weak flanking sequence context. No probable uORF or RG4-forming sequence was detected. Three stem loops were predicted in this region. The ABCA6 protein was found to be expressed in all human tissues (31 tissues tested). The Mode expression score was Low, enhanced in e.g., adipose tissue, bone marrow, brain, esophagus, gallbladder, liver, ovary, testis, and urinary bladder.
