*4.12. Targeted Sequencing*

5 ′UTR sequences of all human ABCA genes were sequenced within a broader set of all exons of 509 genes representing major drug metabolizing and transporting enzymes, nuclear receptors, cell death, chemotherapy target, and signaling pathway genes. The gene panel selection, libraries preparation, sequencing criteria and data analysis, including selection and annotation of variants, were precisely described in Hlavac et al. [57].
