*2.8. ABCA12*

The ABCA12-201 transcript is 9298 bp long and has 53 exons. The 5′UTR spans the first 418 nts. Three separate sub-regions showed the highest level of conservation. Four uATGs (1. −398, 2. −333, 3. −330, 4. −115) were described. The first and third uATGs are conserved within primates (cat. 1), the second and fourth within placental mammals as well as reptiles and birds (cat. 4). The second uATG shows a weak context and the others adequate contexts; all show middle TIS scores. One 69 nt long uORF was predicted starting from −398. No probable RG4-forming sequence was found and six stem loops were predicted in this region. The ABCA12 protein was found to be expressed in many human tissues (17/31). The mode expression score was medium, enhanced in duodenum, kidney, ovary, and small intestine.
