*3.3. Cellular Localization of ABCC6*

ABCC6 is firmly associated with the basolateral membrane of hepatocytes in mice, rats, and humans [74,79,80], as well as in the proximal kidney tubules [81,82]. Although a report challenged the well-established cellular localization of ABCC6 [83], it is interesting to note that disease-causing missense *ABCC6* mutations can lead to aberrant cellular localization [80].
