*2.6. ABCA10*

The human *ABCA10* gene has no known orthologs in ray-finned fishes. The ABCA10-201 transcript is 6362 bp long and has 40 exons. It has the longest 5′UTR among ABCA genes encompassing 910 nts. Three introns (Intron 1–2, 15,668 bp; Intron 2–3, 1295 bp; Intron 3–4, 1615 bp) are annotated within the 5 ′UTR. The most conserved sub-region was determined to −459 to −368. Fourteen uATGs (1. −755, 2. −722, 3. −709, 4. −645, 5. −625, 6. −574, 7. −571, 8. −482, 9. −464, 10. −279, 11. −265, 12. −197, 13. −169, 14. −56) were discovered. The seventh uATG is present only in humans (cat. 0), the first, second, third, fifth, sixth and eighth are conserved within primates (cat. 1), the ninth to fourteenth (last five) are conserved within placental mammals (cat. 3), and the fourth within placental mammals as well as reptiles and birds (cat. 4). The third, fifth, sixth, tenth, and fourteenth uATGs show weak contexts; the first, second, fourth, seventh, and eighth adequate contexts; the ninth, eleventh, twelfth, and thirteenth strong contexts. The fourteenth uATG shows a low TIS score, the fourth and eleventh high TIS scores, and the others middle TIS scores. Six uORFs (start positions-1. −722, 2. −625, 3. −482, 4. −279, 5. −65, 6. −197) were predicted; 33, 117, 42, 33, 171, and 39 bp long, respectively. Interestingly, the sATG of this transcript shows only an adequate flanking sequence context. No probable RG4-forming sequence and five stem loops were predicted in this region. The ABCA10 protein was found to be expressed in many human tissues (40/45). The mode expression score was medium.
