*Present Study*

The current study aimed to evaluate social cognition and social behavior measures in children and adolescents with DS. Evaluated measures included the Developmental Neuropsychological Assessment, Second Edition (NEPSY-II) social cognition subtests and the SRS-2. The first aim of the study was to quantify the number of participants with DS who were able to obtain scores on the measures (i.e., feasibility). Score distributions were also examined to determine if there were floor or ceiling effects. The second aim evaluated test-retest reliability, practice effects, convergent validity, and associations with broader developmental domains (age, cognition, and language). Lastly, additional investigation was completed to determine what ages and cognitive levels were appropriate for administration of any subtest with low feasibility. Psychometric evaluation of social cognition and behavior measures will improve the quality of measurement in DS research and inform future clinical trials.
