**4. Conclusions**

The following conclusions have been drawn:


**Author Contributions:** Investigation, F.L.S.; Methodology, F.L.S., C.S. and M.A.R.; Project administration, M.R.V.L., P.C. and M.A.R.; Supervision, M.R.V.L., P.C. and M.A.R.; Writing—original draft, F.L.S., C.S. and M.A.R.

**Funding:** Financial support from the Regional Government of Castilla-La Mancha (Spain) and European Union (EU, FEDER) through project SBPLY/17/180501/000396 are gratefully acknowledged. CNPq (grants 301492/2013-1 and 465571/2014-0 (INCT-DATREM)) and Capes and São Paulo Research Foundation (FAPESP) (grants #2016/01937-4, #2014/50945-4, #2013/16690-6, #2016/11672-8 and #2017/10118-0) are also acknowledge.

**Conflicts of Interest:** The authors declare no conflict of interest.
