*4.2. Gamma and Mean Shift Correction*

Image brightness is "gamma-corrected", further increasing image contrast by making the color shades of the nuclei more saturated; moreover, the Mean Shift algorithm is applied to make the coloring of the cell nuclei more homogeneous, as shown in Figure 6.

**Figure 6.** Output images of gamma correction step (**a**) and mean shift (**b**).
