**4. Conclusions**

91 Galician honeys obtained from different botanical origins and nectar sources were analyzed to assess their similarities, differences and correlations in terms of phenolic profiles. A miniaturized, fast and environmentally friendly methodology based on VE-UAE-LC-MS/MS was successfully developed. Results revealed the presence of 25 out of the 41 target phenolic compounds in the 91 analyzed samples. TPC and AA were also evaluated, showing mean values around 121 mg GAE 100g−<sup>1</sup> of honey and 340 μmol TRE 100g−1, respectively. ANOVA and PCA results based on TPC, AA and ∑phenolic compounds concentrations, revealed significant differences depending on the honey variety, demonstrating that phenolic compounds can be used as indicators to identify their floral origin. This study proves that the combination of chromatographic analysis with mass spectrometry detection and PCA are suitable tools to investigate the botanical authentication of honey and to guarantee its quality and origin.

**Supplementary Materials:** The following are available online at https://www.mdpi.com/article/ 10.3390/foods10112616/s1, Table S1: concentration (μg g<sup>−</sup>1) of target phenolic compounds, TPC (mg GAE 100g-1) and AA (μmol TRE 100g−1) for: (a) EU, BL, CN and HD; (b) HE and MF honeys in the 2018 season. Table S2: concentration (μg g<sup>−</sup>1) of target phenolic compounds, TPC (mg GAE 100g−1) and AA (μmol TRE 100g−1) for: (a) EU and BL; (b) CN, CN/HD and HD; (c) HE and MF honeys in the 2019 season.

**Author Contributions:** Conceptualization, M.L. and T.D.; methodology, L.V. and D.A.; validation, L.V. and D.A.; formal analysis, L.V. and D.A.; investigation, L.V. and D.A.; data curation, L.V., D.A. and M.L.; writing—original draft preparation, L.V., D.A. and M.C.; writing—review and editing, M.C., M.L. and T.D.; supervision, M.L.; project administration, M.L. and T.D.; funding acquisition, M.L. and T.D. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research was funded by project GO FEADER 2018/054B (Xunta de Galicia). The authors belong to the National Network for the Innovation in miniaturized sample preparation techniques, RED2018-102522-T (Ministry of Science, Innovation and Universities, Spain), and to the Galician Competitive Research Groups IN607B 2019/13 and ED431 2020/06 (Xunta de Galicia). This study is based upon work from the Sample Preparation Study Group and Network, supported by the Division of Analytical Chemistry of the European Chemical Society. All these programmes are co-funded by FEDER (EU).

**Data Availability Statement:** Data are available within the present article and Supplementary Materials.

**Acknowledgments:** The authors wish to acknowledge the Regulator Council of Galician Honey (IXP, Mel de Galicia) for collecting and supplying the samples.

**Conflicts of Interest:** The authors declare no conflict of interest.
