*4.4. Nucleic Acid*

The biomarkers of oxidative damage of nucleic acids—8-Hydroxy-2 -deoxyguanosine (8-OH2dG) and 8-hydroxyguanosine (8-OHG)—can be assessed by ELISA, as well as by direct methods, such as HPLC and GC/MS [224,225]. Elevated levels of 8-OH2dG were reported in the blood of RRMS patients. DNA oxidation products were proposed as diagnostic biomarkers for MS [152] (Tables 3 and 4).
