*2.6. Ethical Aspects*

The study was conducted in accordance with the precepts included in the Belmont report and the Helsinki Declaration (updated at the Seoul Assembly in 2008) for biomedical research. All candidates for entry into the study were informed through a Patient Information Sheet (PIS). Written informed consents were voluntarily signed by the patients. All participants were allowed to leave the study at any time. Subject anonymity and data confidentiality were guaranteed at all times. Finally, the study had the authorization of all participating centers and the permission of the Ethics Committee for Research of Andalusia (Acta nº 271, ref. 3672, approved on 5 December 2017).
