*3.7. Secondary Outcomes: E*ff*ects of Psilocybin on Systolic Blood Pressure, Diastolic Blood Pressure and Heart Rate*

Systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate were evaluated in this meta-analysis as secondary outcomes. The obtained results are summarized in Table 4. As noted, psilocybin produced significant increases in SBP and DBP, up to 6 (*p*-value < 0.017) and 5 h (*p*-value < 0.001) following administration, respectively. The DBP verified increases between 1.194 and 11.381 mmHg, being the average of the increase 7.741 mmHg. Both SBD and DBP tended to stabilize to normal values after 6 or more hours after administration. Psilocybin also significantly increases the heart rate, this increase being highest on the 3rd and 4th hours following administration. Similarly to what was verified for SBP and DBP, heart rate tended to stabilize after 6 or more hours after the administration.


**Table 4.** Meta-analysis for secondary outcomes.

WMD—weighted mean differences; CI—confidence interval; \* Indicates a significant result.
