*3.1. Demographic and Clinical Characteristics of Study Subjects*

The baseline characteristics of the ten study subjects, five responders, and five non-responders, are summarized in Table 1. Mean (standard deviation (SD)) subject age was similar in responders (44.2 (14.2) years) and non-responders (42.8 (16.4) years). There were no significant differences between the two groups in affective symptoms and disease severity, including their scores on the Montgomery and Asberg Depression Rating Scale (MADRS), the Clinical Global Impression-Severity (CGI-S), Beck's Depression Inventory (BDI), the Hamilton Rating Scale for Depression (HAM-D), the Clinically Useful Depression Outcome Scale (CUDOS), and the World Health Organization Quality of Life abbreviated version scores including physical, psychological, social, and environmental quality of life (Supplementary Table S1).


**Table 1.** Demographic and clinical variables of study subjects.

*p*-values appropriately calculated using the Mann–Whitney U test or Fisher's exact test.
