*Article* **Early Depression Independently of Other Neuropsychiatric Conditions, Influences Disability and Mortality after Stroke (Research Study—Part of PROPOLIS Study)**

**Katarzyna Kowalska 1, Łukasz Krzywosza ´nski 2, Jakub Dro´s 3, Paulina Pasi ´nska 4, Aleksander Wilk <sup>5</sup> and Aleksandra Klimkowicz-Mrowiec 1,\***


Received: 19 October 2020; Accepted: 15 November 2020; Published: 17 November 2020

**Abstract:** Post-stroke depression (PSD) is the most frequent neuropsychiatric consequence of stroke. The nature of the relationship between PSD and mortality still remains unknown. One hypothesis is that PSD could be more frequent in those patients who are more vulnerable to physical disability, a mediator variable for higher level of physical damage related to higher risk of mortality. Therefore, the authors' objective was to explore the assumption that PSD increases disability after stroke, and secondly, that mortality is higher among patients with PSD regardless of stroke severity and other neuropsychiatric conditions. We included 524 consecutive patients with acute stroke or transient ischemic attack, who were screened for depression between 7–10 days after stroke onset. Physical impairment and death were the outcomes measures at evaluation check points three and 12 months post-stroke. PSD independently increased the level of disability three (OR = 1.94, 95% CI 1.31–2.87, *p* = 0.001), and 12 months post-stroke (OR = 1.61, 95% CI 1.14–2.48, *p* = 0.009). PSD was also an independent risk factor for death three (OR = 5.68, 95% CI 1.58–20.37, *p* = 0.008) and 12 months after stroke (OR = 4.53, 95% CI 2.06–9.94, *p* = 0.001). Our study shows the negative impact of early PSD on the level of disability and survival rates during first year after stroke and supports the assumption that depression may act as an independent mediator for disability leading to death in patients who are more vulnerable for brain injury.

**Keywords:** post-stroke depression; disability level; mortality
