*3.4. Systolic Blood Pressure*

Figure 4 illustrates the systolic blood pressure. Two transgenic animals could not be assessed because of a lack of vasodilation (1 animal) and overweight (1 animal). The sex effect was observed, with males presenting an increased systolic blood pressure compared to females (S, F (1,30) = 8.163, *p* = 0.008). These differences were especially observed between 3xTg-AD mice (Student *t-*test, *p* = 0.022).

**Figure 4.** Systolic blood pressure. Results are the mean ± SEM. Bars illustrate the genotype groups, as indicated in the abscissae. Symbols are used to illustrate individual values of males (black, left panel) and females (red, right panel). In green: the no-survivors. Genotype (G) and sex (S) effects and GxS interaction were analyzed by 2 × 2 factorial ANOVA analysis, \*\* *p* < 0.01 (above line). Student *t*-test comparisons: \*\* *p* < 0.01, vs. the corresponding NTg group; # *p* < 0.05 vs. the corresponding male group.
