*2.1. Animals and Housing Conditions*

Adult male Wistar rats (Domaszék, Csongrád, Hungary) weighing 150–250 g were used for the experiments at the age of 6–8 weeks. The animals were housed under controlled conditions at constant room temperature, with a 12–12-h light dark cycle (lights on from 6:00 a.m.). The rats were allowed free access to commercial food and tap water.

The animals were kept and handled during the experiments in accordance with the instructions of the University of Szeged Ethical Committee for the Protection of Animals in Research, which approved these experiments. Permission for the experiments (number: X./1207/2018, date: 6 July 2018.) has been granted by the Government Office of Csongrád County Directorate of Food Chain Safety and Animal Health. Each animal was used for only one experimental procedure.
