3.2.1. Elevated Plus Maze

The performance of the mice in this test measuring affective function was analyzed and is presented in Figure S1. The GFAP-ApoE3 and GFAP-ApoE4 mice spent the same amount of time in the open arms, however, males spent more time in the open arm than females, supported by a main effect of sex (*p* < 0.001) and no effect of strain (*p* = 0.366). Treatments did not affect performance (all *p* > 0.185), with the exception of Sed-Aox group spending more time than the Sed-Con group in the open arms (*p* = 0.046). Overall, the GFAP-ApoE3 mice were more active than the GFAP-ApoE4 mice, and some

treatments affected the activity of females (all *p* < 0.003). These observations were supported by the significant main effects of strain and treatment and a sex × strain × treatment interaction. (all *p* < 0.01).
