*2.6. Statistical Analysis*

The functional performance of the mice on the behavioral tests, as well as the biochemical measurements, were assessed using three-way analyses of variance (ANOVA) with sex, genotype, and treatment as between-group factors (or genotype and treatment for catalase measurements due to low *n*). Planned individual comparisons between different sexes, genotypes, and treatments were performed using single degree-of-freedom *F*-tests involving the error term from the overall ANOVA. Some behavioral performances and catalase activity were also considered in four-way analyses with session or brain region as the repeated measure. The software used for the analyses was Systat 13 (San Jose, CA, USA) and *p* was set< 0.05.

#### **3. Results**
