3.2.5. Bridge Walking

The latency to fall was analyzed for each bridge and is presented in Figure 3. On the easiest bridge (session 1), there was no effect of strain, sex, or treatment on the latency to fall (all *p* > 0.13). In session 2, females performed better than males leading to a main effect of strain. While there was no main effect of treatment, exercised groups had higher latencies in males regardless of strain but it only reached significance for the Ex-Aox GFAP-ApoE3 mice (*p* = 0.029). In session 3, a main effect of treatment was obtained (*p* = 0.03) due to all treatments in male GFAP-ApoE3 mice. In session 4, treatments, especially exercise, were associated with increased latencies in the GFAP-ApoE3 but not GFAP-ApoE4 groups. GFAP-ApoE4 females performed better than their male counterparts, driving the main effects of sex and strain (all *p* < 0.03).

**Figure 3.** Exercise and antioxidants improved balance in male and female GFAP-ApoE3 mice but not in GFAP-ApoE4 mice. Each value represents mean ± SEM, *n* = 8–16. \* *p* < 0.05 vs. sex- and strain-matched Sed-Con groups; † *p* < 0.05 comparing strain-matched Sed-Con males and females.
