3.2.2. Spontaneous Activity

Horizontal distance and rearing activity were analyzed (Figure S2). GFAP-ApoE4 mice travelled 40% shorter distances than the GFAP-ApoE3 mice, and GFAP-ApoE3 females traveled 18% more than their male counterparts. Treatment had no effect on distance traveled. An ANOVA yielded a main effect of strain (*p* < 0.001) and no effect for treatment, sex or any interactions between the factors (all *p* > 0.300). GFAP-ApoE4 mice also spent 20% less time rearing than the GFAP-ApoE3, supported by a main effect of strain (*p* = 0.001). Most treatments had no effect on the rearing activity of the mice with the exception of Sed-Aox, which increased it (*p* = 0.046).
