3.2.4. Reflexive Musculoskeletal Responses

Performance was averaged over four sessions and is presented in Figure S3. GFAP-ApoE4 mice took longer latencies than the GFAP-ApoE3 mice to initiate walking, supported by a main effect of strain (*p* = 0.019). There was no effect of treatment, sex, or interactions between any of the factors (all *p* > 0.086). Alley-turning was affected differentially by the treatments depending on sex and genotype (sex × strain × treatment interaction, *p* = 0.004). GFAP-ApoE4 females took longer latencies than the GFAP-ApoE3 females, while there was no difference in males. In GFAP-ApoE4 females, Sed-Aox took longer to turn, while in GFAP-ApoE3, the Ex-Aox males had the shortest latency. For negative geotaxis, males took longer latencies to turn, as well as GFAP-ApoE4 mice. The Sed-Aox mice had shorter latencies in the GFAP-ApoE3 groups (strain × treatment, *p* = 0.058). Latency to tread was affected by strain (*p* = 0.01), due mainly to treatments affecting each genotype differently (higher in GFAP-APoE4 males vs. lower latencies in GFAP-ApoE3 mice). There was no effect of treatment or interactions between any of the factors (all *p* > 0.10).
