**5. Conclusions**

Exercise was the most consistent treatment effective at improving motor and cognitive function, and the addition of antioxidants did not lead to major additive or antagonistic effects. ApoE4 mice were less responsive to the treatments than the ApoE3 mice, suggesting a genotype-dependent response to interventions. Therefore, factors such as sex, age, genotype, and chosen tests need to be carefully incorporated into preclinical studies of interventions to improve brain function during aging or neurodegenerative diseases.

**Supplementary Materials:** The following are available online at http://www.mdpi.com/2076-3921/9/6/553/s1, Figure S1: Effect of exercise and antioxidant on performance on the elevated plus maze in male and female GFAP-ApoE3 and GFAP-ApoE4 mice, Figure S2: Effect of exercise and antioxidant on spontaneous activity in male and female GFAP-ApoE3 and GFAP-ApoE4 mice, Figure S3: Effect of exercise and antioxidant on reflexes in male and female GFAP-ApoE3 and GFAP-ApoE4 mice, Figure S4: Effect of exercise and antioxidant on catalase activity from different brain regions from GFAP-ApoE3 and GFAP-ApoE4 mice.

**Author Contributions:** Conceptualization, K.C. and N.S.; methodology, K.C., J.M.W., T.C., S.E.O., P.H.V.; formal analysis, K.C.; writing—original draft preparation, K.C.; writing—review and editing, N.S.; supervision, N.S.; project administration, N.S.; funding acquisition, S.E.O. and N.S. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research was funded by the Alzheimer's Association, grant number NIRG-10-173988, by the Pine Family Foundation (gift) and by UNT HSC Bridge Funding, grant number RI6096.

**Conflicts of Interest:** The authors declare no conflict of interest.
