*2.2. Solid-State Studies*

Procedures for the preparation of inclusion complexes of efavirenz and γ-CD as solid materials comprised combining two separate solutions of each component. Efavirenz, dissolved in ethanol, was mixed with γ-CD, dissolved in ultrapure water, to obtain a clear mixed solution that was subsequently subjected to snap-freezing and freeze-drying. In agreement with the information obtained from the studies in solution, two different host-to-guest stoichiometries were tested, 3:2 and 1:1.
