*3.2. Instrumentation*

<sup>1</sup>H and <sup>13</sup>C NMR spectra were recorded at 25 ◦C with a VARIAN UNITY PLUS-500 spectrometer at 499.9 and 125.7 MHz, respectively, using Varian library standard pulse programs. All samples were prepared in deuterated solvents (D2O); <sup>1</sup>H NMR spectra were referred to the HOD signal and <sup>13</sup>C NMR spectra to acetone (external reference). In all the experiments, the pulse at 90◦ lasted about 7 µs. 2D experiments (COSY, HSQC and HMBC) were acquired using 1K data points and 256 increments.

UV-Vis spectra were recorded with a VersaWave microvolume UV/Vis spectrophotometer (Expedeon, Ottawa, ON, Canada). The molar absorptivity of DOX 10,410 (mol−<sup>1</sup> L cm−<sup>1</sup> ) at 482 nm was used.
