3.1.2. Synthesis of PGAβCyDArg2

The synthesis was carried out as described above with PGA (7 mg), DMTMM (18 mg), ArgOCH<sup>3</sup> (6 mg), DMTMM (10 mg) and βCyD3NH<sup>2</sup> (50 mg).

<sup>1</sup>H NMR (500 MHz, in D2O) δ (ppm): 5.16-4.75 (H-1 of CyD); 4.28 (s, CH Glu); 4.20 (m, CH Arg); 4.10–3.20 (m, H-3, -6, -5, -2, -4 of CyD, OCH3); 3.13 (m, γ-CH<sup>2</sup> Arg); 2.58–1.60 (m, γ-CH<sup>2</sup> PGA,); 1.35 (m, CH<sup>2</sup> butyl chain of PGA), 1.6 (m, CH<sup>2</sup> butyl chain of PGA ); 1.28 (m, CH<sup>2</sup> butyl chain of PGA), 0.89 (m, CH<sup>3</sup> butyl chain of PGA).

Dimension (DLS, Z average): 35 ± 2 nm; PDI (DLS): 0.5; Zeta potential: 7.7 ± 0.5 mV (pH = 7.4).
