*4.1. Material*

A549 (ATCC® CCL185™) and THP-1 (ATCC® TIB-202™) cells were purchased from the American Type Culture Collection (Manassas, VA, USA). HPβCD was obtained from Roquette, Lestrem, France. H2O2, Lipopolysaccharides (LPSs), Budesonide (BUD), Phorbol Myristate Acetate (PMA), MβCD, sphingomyelinase from Bacillus cereus, *N*-acetyl-l-cysteine (NAC), 2,2-Diphenyl-1-picrylhydrazyl (DPPH•), and l-ascorbic-acid (vitamin C) were ordered from Sigma-Aldrich (Saint Louis, MO, USA). A Cytotoxicity Detection KitPLUS (LDH) was ordered from Roche (Mannheim, Germany) and HOECHST® 33,342 staining solution from Life technologies (Eugene, OR, USA). LY294002 was ordered from Gibco (Camarillo, CA, USA). Phospho-Akt (Ser473) (D9E) XP® and Akt rabbit monoclonal antibodies were obtained from Cell Signaling Technology® (Beverly, MA, USA). β-actin (C4), mouse IgGκ light chain binding protein (m-IgGκ BP) conjugated to horseradish peroxidase (HRP) and mouse antirabbit IgG-HRP monoclonal antibodies were obtained from Santa Cruz Technology (Dallas, TX, USA). Horseradish Peroxidase (HRP) was ordered from Thermo ScientificTM (Rockford, IL, USA). Anti-HDAC2 (Ab-394) and Anti-phospho-HDAC2 (pSer394) antibodies produced in rabbit were ordered from Sigma-Aldrich (Saint Louis, MO, USA). Phenolsulfonphtalein (phenol red) was obtained from Merck (Darmstadt, Germany). A Human IL-8/CXCL8 DuoSet ELISA kit was obtained from R&D systems (Minneapolis, MN, USA). Trimethylsilyl-3-propionide acid-*d4* (TMSP) and deuterium oxide (99.96% D) were purchased from Eurisotop (Gif-sur-Yvette, France). Certified maleic acid and phosphate buffer powder were provided by Sigma-Aldrich (Karlsruhe, Germany). NMR measurements were recorded on a Bruker Avance spectrometer operating at 500.13 MHz for the proton signal acquisition and equipped with a 5-mm TCI cryoprobe with a Z-gradient.
