*2.2. Compatibility Studies of RSP/RM-β-CD Inclusion Complex with Excipients*

The compatibility of RSP with several pharmaceutical excipients, namely microcrystalline cellulose, anhydrous lactose, starch, sodium lauryl sulfate, and magnesium stearate has been assessed and drug–excipient incompatibility has been reported in the presence of magnesium stearate, lactose, and microcrystalline cellulose [44]. In order to evaluate the ability of RM-β-CD to prevent the incompatibilities between drug substance and the mentioned excipients, compatibility studies of inclusion complex and excipients were conducted using thermal and spectroscopic techniques.
