*3.1. Materials*

The water-soluble polymer butyl-polyglutamate (20) sodium salt (3 KDa, PGA) was acquired from IRIS Biotech gmbh. 3A-amino-3A-deoxy-2A(S),3A(R)-β-cyclodextrin (βCyD3NH2), 3A-amino-3A-deoxy-2A(S),3A(R)-γ-cyclodextrin (γCyD3NH2) and DOX

were acquired from TCI (Tokyo Chemical Industry). L-Arginine methyl ester dihydrochloride was acquired by SIGMA Aldrich. Aβ1-40 (Bachem) was properly treated, as previously reported [32]. Inclusion complexes of DOX with CyD polymers were prepared by mixing the stock solution of DOX with solutions of CyD polymers for 2 h.
