*4.2. BUD:HP*β*CD Complex Stock Solution Preparation and Characterization*

We adapted the method of Dufour et al. [64]. The BUD:HPβCD complex stock solutions were prepared by adding 200 mM HPβCD (molar substitution = 0.64) in deionized water to BUD powder at a final concentration of 8.13 mM (BUD:HPβCD 1:25 molar ratio). The solution was then thoroughly mixed for 1 h 30 min (13,500 rpm) with a T25 basic Ultra-Turrax® homogenizer from IKA (Staufen, Germany) and filtered (0.22-µm filter unit). BUD and HPβCD were quantified in the solution obtained by HPLC-UV and <sup>1</sup>H-NMR, respectively, and checked for complexation as described by Dufour et al. [64]. Solutions were stored at 4 ◦C and renewed every 2 months.
