**3. Results**

Herein we present how our computational model (Appendix A) behaves under normal physiological conditions and how its output is affected by the mitochondrial dysfunction. We first focus on the mitochondrial ATP production and the so-called energy-driven metabolic switch, the main determinants for glucagon and insulin secretion in alpha and beta cells, respectively. Then, we further explore how pathologically altered ATP generation affects the hormonal secretion process.
