Regulatory:


**Author Contributions:** Conceptualization, A.K., C.L.G., I.A.U. and K.V.G.; writing—original draft preparation, A.K., C.L.G., I.A.U.; writing—review and editing, A.K., C.L.G., I.A.U. and K.V.G.; visualization, A.K., C.L.G., I.A.U.; supervision, K.V.G.; project administration, K.V.G.; funding acquisition, K.V.G.; All authors have read and agreed to the published version of the manuscript.

**Funding:** This work was partly sponsored by the Novo Nordisk Foundation in the frame of the "Accelerated Innovation in Manufacturing Biologics" (AIMBio) project (Grant number NNF19SA0035474).

**Conflicts of Interest:** The authors declare no conflict of interest.
