Diagnosis

GA diagnosis is supported when anti-tTG, anti-gliadin, and anti-TG6 (anti-transglutaminase 6) antibodies are found in the serum. The best diagnostic approach for patients with suspected GA remains unclear. Still, one study reported that considering the whole spectrum of gluten, the IgG anti-gliadin antibody performs better than the gluten ataxia marker because of its elevated sensitivity [149].

Studies of GA patients have shown that the brain presents anti-tTG antibodies. If CD serology is positive, it is necessary to look for evidence of CD through an intestinal biopsy [150]. Magnetic resonance imaging (MRI) can be utilized to diagnose GA. MRI results from up to 60% of GA patients show evidence of moderate cerebellar atrophy [151].
