**5. Conclusions**

Both VPT and NPT present high clinical efficacy in primary teeth. The results should be interpreted with caution, as the quality of SRs included is overall moderate. Welldesigned clinical trials and high standard systematic reviews are necessary to verify the efficacy of treatment options, clinical outcome efficacy, and material suitability.

**Supplementary Materials:** The following are available online at https://www.mdpi.com/article/ 10.3390/jcm11010085/s1, Table S1: PRISMA 2020 Checklist, Table S2: Detailed list of excluded articles with reasons.

**Author Contributions:** Conceptualization, L.B.L., C.C. and F.S.V.; methodology, J.B. and V.M.; validation, L.B.L., J.A.N. and J.B.; formal analysis, J.B. and V.M.; investigation, C.C. and F.S.V.; resources, J.J.M.; writing—original draft preparation, L.B.L. and J.A.N.; writing—review and editing, V.M., J.B. and J.J.M.; supervision, L.B.L.; project administration, J.J.M.; funding acquisition, J.J.M. All authors have read and agreed to the published version of the manuscript.

**Funding:** This work is financed by national funds through the FCT—Foundation for Science and Technology, I.P., under project UIDB/04585/2020.

**Institutional Review Board Statement:** Not applicable.

**Informed Consent Statement:** Not applicable.

**Data Availability Statement:** Data is available in the manuscript. Any further information is available upon request on the corresponding author.

**Conflicts of Interest:** The authors declare no conflict of interest.
