3.2.2. Participants

In total, of the 18 articles [16–33] evaluating regeneration outcomes, 14 articles [16–28,33] were randomized clinical trials, and 4 articles [29–32] were non-randomized clinical articles. In randomized clinical trials, a total of 393 participants and 412 teeth were included. In non-randomized clinical trials, 144 participants and 156 teeth were included.

Five articles [34–38] evaluated apexification outcomes, of which two articles [34,35] were randomized clinical trials and three [36–38] were non-randomized clinical trials. In RCT, a total of 68 participants and 68 teeth were included. In NRCT, a total of 198 participants and 200 teeth were included. One NRCT article was a multicentric study.

Nine articles [39–47] compared the outcome between regeneration and apexification procedure, of which two articles [39,40] were RCTs, and seven articles [41–47] were NRCTs. In the RCTs, a total of 133 participants and 133 teeth were included. In the NRCTs, a total of 439 participants and 446 teeth were included.
