**5. Conclusions**

Our findings sugges<sup>t</sup> that the BCS filling technique may positively affect POP, while there was a trend of a beneficial effect for analgesic intake, incidence of flare-up, pulp status, and number of visits when using BCS, compared with RBS. However, due to several limitations in these analyses, further well-designed clinical studies are warranted to supplement our results.

**Supplementary Materials:** The following are available online at https://www.mdpi.com/article/ 10.3390/jcm10194509/s1, Table S1: Excluded studies with reasons for exclusion, Figure S1: Forest plot of flare-up after RCF with BCS vs. RBS, Figure S2: Diagram of pain characteristics summary in a subgroup of BCS and RBS traditional filling technique groups 24 h after RCF, Figure S3: Diagram of pain characteristics summary in a subgroup of BCS and RBS traditional filling technique groups 48 h after RCF, Figure S4: Forest plot of POP in patients treated with warm and cold filling techniques 24 h after RCF with BCS vs. RBS, Figure S5: Forest plot of POP in patients treated with warm and cold techniques 48 h after RCF with BCS vs. RBS, Figure S6: Forest plot of POP in vital and non-vital pulp 24 h after RCF with BCS vs. RBS, Figure S7: Forest plot of POP in vital and non-vital pulp 48 h after RCF with BCS vs. RBS, Figure S8: Forest plot of POP following retreatment 24 h after RCF with BCS vs. RBS, Figure S9: Forest plot of POP following retreatment 48 h after RCF with BCS vs. RBS, Figure S10: Forest plot of POP 24 h after RCF with BCS vs. RBS following a single or multiple visit treatment.

**Author Contributions:** Conceptualization, D.P., M.D.F. and E.B.; methodology, D.P., M.D.F. and E.B.; software, E.M., M.A., N.S., A.C., M.C. and M.T.; data analysis, E.M., M.A., N.S., A.C., M.C. and M.T.; visualization, E.M., M.A., N.S., A.C., M.C. and M.T.; supervision and project administration, D.P., M.D.F. and E.B.; writing, E.M., D.P. and M.D.F.; reviewing and editing, D.P., M.D.F., E.M., M.A. and E.B. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding.

**Institutional Review Board Statement:** Not applicable.

**Informed Consent Statement:** Not applicable. **Conflicts of Interest:** The authors declare no conflict of interest.
