*Proceeding Paper* **Propelling the Penetration of Electric Vehicles in Pakistan by Optimal Placement of Charging Stations †**

**Hafiz Owais Ahmed Khan, Faisal Saeed \* and Naveed Arshad**

SBA School of Science and Engineering, Lahore University of Management Sciences (LUMS), Lahore 54792, Pakistan; 19060025@lums.edu.pk (H.O.A.K.); naveedarshad@lums.edu.pk (N.A.)

**\*** Correspondence: 19060005@lums.edu.pk

† Presented at the 2nd International Electronic Conference on Applied Sciences, 15–31 October 2021; Available online: https://asec2021.sciforum.net/.

**Abstract:** The world is rapidly advancing towards the electrification of mobility owing to the substantial benefits of emission reduction. Adhering to international trends and environmental obligations, the Government of Pakistan (GOP) also intended to adopt 30@30 plug-in-electric vehicles (PEVs) across the country, which implies 30 percent of new sales will be of PEVs until 2030. Despite the policy guidelines introduced by the GOP as well as incentives for vehicle fleet electrification and indigenization, the foremost challenge is the lack of a PEV charging infrastructure placement plan for the country. In this regard, an optimal locality map for level-3 or direct current fast charging (DCFC) stations' installation is proposed, considering traffic volume, service area, and local grid facility while ensuring the availability of charging stations across all major networks of the country. The area of focus for this is National Highway 5, known as N5, and the Motorway-2 (M2) Network. The paper also provides insights into the techno-economic analysis of the proposed charging station installation spots. The results are extremely encouraging and reveal the proposed PEV charging stations under observation on the highways from Lahore to Islamabad consumed an electricity share of 3 MW–0.13 MW based on minimum to maximum traffic volume scenarios, respectively. The study is impactful and ultimately paves a way forward for the aggravation of the EV market share by considering the initial investment and a payback period of 7 months. With the help of this study, better planning in terms of EV penetration size and its requirement for public DCFC stations can be implemented, and the exact recipe for the growth of the supportive industry with the pace of PEVs' perforation can be executed.

**Keywords:** charging stations; PEVs; optimal location; DCFC; route node coverage; techno-economic analysis

Academic Editor: Nunzio Cennamo

**Citation:** Khan, H.O.A.; Saeed, F.; Arshad, N. Propelling the Penetration of Electric Vehicles in Pakistan by Optimal Placement of Charging Stations. *Eng. Proc.* **2021**, *11*, 34. https://doi.org/10.3390/ ASEC2021-11189

Published: 15 October 2021

**Publisher's Note:** MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

**Copyright:** © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

**1. Introduction**

Fossil-fuel-based internal combustion engines (ICEs) are one of the key factors which account for 50% of environmental pollution [1]. Developing countries suffer more because of old and inefficient engines used in their transportation network which are the cause of transport-generated pollution, particularly in Asia, Africa, and the Middle East, ranging from 12 to 70% [2,3]. The challenge of transportation pollution can only be overcome by changing the transport fleet from ICE to plug-in electric vehicles (PEVs) [3]. To encourage maximum PEV penetration, there must be a coordinated network of fast charging stations available publicly with private parties involved to also enable the rapid market penetration of PEVs. In recent years, many researchers have focused on the optimal placement of charging stations by continuing to study areas such as the environment, commerce, selfsustainability, etc. [4–7].

Presently, Pakistan lacks a PEV charging infrastructure plan to facilitate the adoption of PEVs on a wide scale in the country. To solve this problem robustly, a similar approach as discussed in [7] is adopted with slight improvements in a model for the optimal placement of direct current fast charging (DCFC) stations based on the flow calculation by using the dataset provided by the National Highways and Motorways authority. The considered networks for this contextual analysis are the Motorway 2 (M2) and National Highway 5 (N5) networks from Lahore to Islamabad. These routes are more active traffic routes than the rest of the road networks in the country, and also, the region covering these routes is among the most densely populated areas of the country. Moreover, the study is focused on proposing an optimal PEV charging station plan for intercity routes to ensure long-range, anxiety-free traveling in the future.

#### **2. Electrical Charging Stations Locality Deployment Model**

To maximize PEVs' market share, a coordinated charging station (CS) network along highways and motorways is suggested. In this study, all vehicles were considered as cars, and heavy-duty traffic was not considered. Charging time was assumed to be 30 min for standardization, and the charger electricity consumption was 50 KW. The PEV charging port and CS charging port adopted the same type of standardization for the convenience of installation purposes. The tariff was assumed to be 35 rupees for dedicated load EV charging by the distribution companies and an annual 10% rupee devaluation. As the charging process interrupts the journey, only DCFC chargers were considered. To determine CS sites, we only considered rest-places with basic rest-place facilities as candidate sites. These facilities are available on the candidate site and also no farther than 250 m from it and are categorized as: (i) *basic facility location:* parking, small shops, and prayer provision (ii) *medium facility location:* supermarket, dining court, and minimum rest-place facility (iii) *superior facility location:* High-end rest and accommodation facility, food courts, and additional facilities such as a pharmacy, etc. By considering these facilities, the potential location of CSs could be selected based on the re-defined equation detailed in [7] for each nominated site, and the process is illustrated in Figure 1.

$$PL\_i = a\_1 \mathbf{x}\_{1,i} + a\_2 \mathbf{x}\_{2,i} + a\_3 \mathbf{x}\_{3,i} + a\_4 \mathbf{x}\_{4,i} + a\_5 \mathbf{x}\_{5,i} \tag{1}$$

where *PLi* = potential location of candidate site, '*i*', *x*1,*<sup>i</sup>* = security level on nearby roads at the candidate site, '*i*', *x*2,*<sup>i</sup>* = evaluation value of traffic volume on nearby roads at the candidate site, '*i*', *x*3,*<sup>i</sup>* = evaluation value of service level of the candidate site, '*i*', *x*4,*<sup>i</sup>* = evaluation value of the distance between two candidate sites, '*i*', *x*5,*<sup>i</sup>* = electricity availability at the candidate site '*i*', while *a*1, *a*2, *a*3, *a*4, and *a*<sup>5</sup> are the weights of variables.

**Figure 1.** Algorithm for optimal location determination for installation of PEV charging stations.

The parameters in (1) require exploration for the precise determination of optimal CS spots. In (1) *x*1,*<sup>i</sup>* is the security factor for the CSs as well as for the nearby roads. The value of '*x*2,*i*' is the sum of average daily traffic volume that passes through national highways and motorways within the range of 20–100 km (Km) from the CS (*Ni*) (vehicle/day) location. We considered the traffic volume of the directions from where the rest-place is accessible. The value of *x*<sup>1</sup> is calculated according to the equation below [7]:

$$\mathbf{x}\_{1,i} = \begin{cases} 0, & \text{if } N\_i \le f \text{min} \\ \frac{N\_i - f \text{min}}{f \text{max}} \, 0.5, & \text{if } f \text{min} < N\_i < f \text{max} \\ 1, & \text{if } N\_i \ge f \text{max} \end{cases} \tag{2}$$

where *Ni* = number of vehicle flow, and *fmax* = maximum vehicle flow *f min* = minimum vehicle flow. We defined the limit values according to the calculations by using the dataset. In terms of service level, *x*3,*i*, a basic service facility is ranked as 1, medium is ranked as 2, while a superior service level at CS locations is given a rank of 3. *a*4*x*4,*<sup>i</sup>* is assumed to be constant as the distance between two candidate sites on the motorway network is fixed (service areas also have a fixed location), while on the N5 network, a supposition is made that there must be a charging station after every 40 km. Additionally, *x*5,*<sup>i</sup>* factor ensures the availability of national power grids, transmission, and distribution networks for PEV CS integration at each candidate site.

#### **3. Results and Discussions**

To determine the optimal charging station locations based on the dataset, vehicle flow was calculated at N5 north, from Lahore to Islamabad, and at motorway M2 from Islamabad to Lahore. The dataset consisted of data of vehicle flow for April 2019 as depicted in Figure 2a,b, and for March 11 to the April 14 of the year 2020, respectively, as shown in Figure 2c. This particular dataset is important because it covered the pre-COVID-19 (2019) as well as the post-COVID-19 (2020) period. So, in this way, we gained the regular maximum vehicle flow data as well as the minimum vehicle flow data. Due to the availability of minimum vehicle flow data, different case scenarios could be developed, and we also learned the minimum amount of the traffic that would flow in any bad scenario.

**Figure 2.** Vehicle flow data pre-COVID scenario on (**a**) M2; (**b**) N5; and (**c**) post-COVID scenario of M2 and N5.

Considering the provision of facilities, the study area was divided into different zones on M2 and N5, as shown in Figure 3. The zones were divided according to the traffic data and the nature of the facilities available. The PEV population was distributed between these zones. Considering the zones, proposed locations with distances in-between the two CSs are enlisted in Table 1. Further, battery size and the mileage range of different models of cars were also considered for this investigation (see Table 2 [8]). From the dataset, the average vehicle flow was calculated in the normal period as well as during the COVID-19 period (see Tables 3 and 4) by adopting approach detailed in [9,10]. By assuming the differences ranged from 1% to 10%, we developed the scenarios as listed in Tables 5 and 6 for the N5 and M2 highways, respectively. In this way, the goal of the research effort to establish a certain number of priority CSs was accomplished by maximizing the service of charging stations. It is to be noted that when calculating the distance from the demand point to the candidate point, the mathematical model mentioned in (1) and (2) and the after-mentioned principles were adhered to for the optimal placement of PEV CSs. The finalized scenario including transmission network infrastructure and the proposed potential charging station candidates for the M2 and N5 routes are depicted in Figure 4.


**Table 1.** Proposed Charging Station Locations and Distance.


**Table 2.** Travelling Range of Different Electrical Vehicle Cars [8].

**Table 3.** Percentage of Electric Vehicle Flow in Normal Days.


**Table 4.** Percentage of Electric Vehicle Flow in COVID-19.


**Table 5.** Power consumption at 15 Stations of N5.


**Table 6.** Power consumption at 5 stations of M2.


**Figure 3.** Zones to be covered for proposed PEV charging installation on (**left**) N5 north; and (**right**) M2 from Lahore to Islamabad. It is to be noted that figures are not according to the scale and only indicate the approximate zone areas.

**Figure 4.** Proposed candidate sites for PEV charging stations on M2 motorway and N5 with transmission network.

Further, economic analysis about the investment and payback period was also taken into account for a feasibility analysis of the proposed model. For this, we considered the initial cost of investment, variable cost, operational cost, etc., as listed in Table 7.

**Table 7.** Economic analysis parameters for the installation of PEV CSs.


The charger mentioned above is the DCFC, with two ports for charging at one time. The installation cost included the labor cost, material cost, and other such parameters; the new connection cost was the cost of the regulator, and in the case of the transformer, there was a minimum cost both for the regulator and transformer. The operational and maintenance cost was taken as the 10% annual cost. The electricity and taxes costs were obtained from the provider, while we had to consider the rupee devaluation for investment and some miscellaneous charges, as this is the new technology, and there will inevitably be some unknown annual charges. Even during the period of strict lockdown during the COVID-19 pandemic, the minimum EV flow was 3 at each point in 1 h. So, at least two chargers are needed at one optimal location point. If the charging cost is assumed to be 0.31 USD/KWh and the installed charger worked for 24 h, then:

Total 1 day selling cost = 0.31 \* (24 \* 2) \* 50 KW = 744 USD/KWh; Total 30 days selling cost = 22,320 USD/KWh, while:

Total 30 days actual electric cost is = 18,144 USD/KWh. Profit for 30 days = 4176 USDKWh. Total investment recovery time = 29,400/4176 = 7 months.

So, in almost 7 months, the total investment will be recovered, even when the devaluation (or, if we remain in dollars, considering the interest rate at 10%) is also considered.

#### **4. Conclusions**

In the implementation process, a N5 road and motorway map was derived, and the results are presented in the above section. To address the problem of location selection during electric vehicle charging station planning, this paper proposed a location method based on regional information and future predicted demand. According to the battery life of an electric vehicle, we determined the service range of a charging station. Based on the cost constraints, we determined the number of CSs to determine the optimal location for a PEV CSs. The method proposed in this paper can obtain an ideal charging station planning scheme that meets requirements and provides a guiding significance and application value for the location and constant volume of an electric vehicle charging station.

**Author Contributions:** Conceptualization, H.O.A.K., N.A.; methodology, H.O.A.K., F.S., N.A.; validation, H.O.A.K., F.S., N.A.; formal analysis, H.O.A.K., F.S., N.A.; investigation, H.O.A.K., F.S., N.A.; resources, H.O.A.K., N.A.; data curation, H.O.A.K., N.A.; writing—original draft preparation, H.O.A.K., F.S., N.A.; writing—review and editing, H.O.A.K., F.S., N.A.; visualization, H.O.A.K., F.S., N.A.; supervision, N.A.; project administration, N.A.; All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding.

**Institutional Review Board Statement:** Not applicable.

**Informed Consent Statement:** Not applicable.

**Data Availability Statement:** Not applicable.

**Acknowledgments:** The authors would like to acknowledge the various support of the National Highway Authority (NHA) of Pakistan on the provision of traffic flow data for the successful completion of this research study.

**Conflicts of Interest:** The authors declare no conflict of interest.

#### **References**


## *Proceeding Paper* **Quantification of Losses in a Photovoltaic System: A Review †**

**Faisal Saeed 1,\* and Abdullah Zohaib <sup>2</sup>**


**Abstract:** In this paper, we characterized and reviewed the emergence of fundamental and extended losses that limit the efficiency of a photovoltaic (PV) system. Although there is an upper theoretical bound to the power conversion efficiency of solar cells, i.e., the Shockley Queisser limit, in a practical environment, the consideration of inevitable losses in a whole PV system is imperative to optimally harvest solar energy. In this regard, this study quantifies the losses from a PV cell level to the whole PV system. It was perceived that reported losses on the PV cell level included the low energy bandgap, thermalization, recombination (surface and bulk recombination), optical absorption, space charge region, finite thickness, and metal contact loss, and it was determined that cutting techniques mainly constrained the power conversion efficiency of the solar cell. Furthermore, the detailed PV array losses were classified as mismatch power losses, dust accumulation losses, temperature effects, material quality losses, and ohmic wiring losses. The unavoidable system losses were quantified as inverter losses, maximum power point tracking losses, battery losses, and polarization losses. The study also provides insights into potential approaches to combat these losses and can become a useful guide to better visualize the overall phenomenology of a PV System.

**Keywords:** PV cell; PV modules; losses; quantification

#### **1. Introduction**

In the last few years, photovoltaics (PV) have emerged as a pioneer technology to meet the energy demands of small-scale consumers to those of the commercial sector and provide a cost-beneficial solar power generation system that can be used to offset the electricity costs from utility providers as well as alleviate the burden on the national electricity grid. Another major advantage of PV systems is the emission reduction benefits [1,2]. Presently, the installed PV capacity is around 109 G*Wp*, and this could cross 149 G*Wp* by 2022 according to the International Energy Agency (IEA), France [3]. This trend certainly demonstrates unparalleled progress in efficiency enhancement in the area of photovoltaics combined with power electronic-aided hybrid converters as well as cutting edge cost benefits, yet the emergence of losses in real environmental conditions is inevitable, as these losses cannot be eliminated beyond fundamental limits [4–6].

PV cells harvest solar energy to yield photogenerated power. The performance of solar cells depends on the available solar insolation and the spectral distribution of incident wavelengths over the surface of the PV system. The output of the solar cell is generally measured in standard testing conditions (STC); irradiance 1000 W/m2, temperature 25 ◦C, and standard earth spectrum AM 1.5 G, where G stands for global and includes both direct and diffuse radiation [7–9]. The solar cell performance is characterized based on parameters including open-circuit voltage (*Voc*), the voltage at the maximum power point (*Vmp*), the short circuit current (*Isc*), current at the maximum power point (*Imp*), and the maximum power point (*Pmp*), which can be extracted from the current–voltage (I–V) characteristics

**Citation:** Saeed, F.; Zohaib, A. Quantification of Losses in a Photovoltaic System: A Review. *Eng. Proc.* **2021**, *11*, 35. https://doi.org/ 10.3390/ASEC2021-11200

Academic Editor: Nicholas Vassiliou Sarlis

Published: 19 October 2021

**Publisher's Note:** MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

**Copyright:** © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

shown in Figure 1 [5]. The efficiency (*η*) of the solar cell is the ratio of available solar energy to the converted electrical energy, which can be calculated using the percentage of the maximum power point and the surface area of the solar cell (A) into irradiance (*Ir*), which is provided by Equation (1).

$$\eta = \frac{P\_{\text{mp}}}{A \times I\_r} \text{ (\%)} \tag{1}$$

$$\eta = \underbrace{\eta \stackrel{\text{Follance (V)}}{\text{ }}}\_{\text{Velocity}} \tag{1}$$

$$\eta = \underbrace{\eta \stackrel{\text{Follance (V)}}{\text{ }}}\_{\text{Fillance (V)} \text{ }} \tag{1}$$

**Figure 1.** Generic current–voltage (I–V) and power–voltage (P–V) characteristics of a photovoltaic cell [5].

In real environmental conditions, several factors affect the performance of PV cells. Herein, we first reviewed the major losses from PV cells to the overall PV system and subsequently characterized and presented the losses in a pictorial form for better visualization and understanding for the reader.

#### **2. Quantification of Losses in a Photovoltaic System**

#### *2.1. Losses in a Photovoltaic Cell*

The loss mechanisms in a PV cell are initiated by the fundamental inability of the solar absorber-layer material (silicon, gallium arsenide, perovskite, copper indium gallium selenide (CIGS), among others) to potentially absorb all incident light wavelengths [10]. Incident light wavelengths with a photon energy (*Eph*) less than the energy bandgap (*Eg*) of the absorber layer are unable to be absorbed. Such losses are the *below energy band gap losses* and are shown mathematically by Equation (2) [11].

$$\text{Below Eq Loss} = \int\_0^{E\_{\text{S}}} E \cdot GP(E, \Omega\_{A\prime}, T\_{S\prime}, \mu = 0) dE \tag{2}$$

The photons with energy *Eph* > *Eg* generate electron–hole pairs. However, the carriers with high kinetic energy sometimes decay to the band edges quickly from their initial excited states to reach their thermal equilibrium states, releasing their excess energy upon interaction with the crystal lattice. Such losses can be categorized under *thermalization loss*, and the mathematical relationship is given in Equation (3) [12–14].

$$Thermalization\,loss = \frac{\text{Eg } \int\_0^{\lambda g} \Phi(\lambda) d\lambda}{\int\_0^{\lambda g} \Phi(\lambda) \frac{\text{k}\varepsilon}{\lambda} d\lambda} \tag{3}$$

Thermodynamic studies on a PV cell demonstrated that at temperature > 0 K, a voltage drop is associated with the PV cell, which is termed as *etendue loss* [15]. Moreover, *Fermi level losses*; losses associated with the displacement of the *Voc* and *Eg* relationship and *electron kinetic losses; and* losses underlying the inefficacious use of the carriers' kinetic energy during the thermalization process are among the major thermodynamic losses that limit the efficiency of solar cells [14–16]. Besides this, operating solar cells at *Pmp* could also result in reduced output performance because of series and shunt resistance effects and is referred to as *fill factor loss* [17].

In practical scenarios, part of the incident light that falls on the surface of a solar cell is reflected or transmitted instead of being absorbed. Such losses are referred to as *optical losses* [18]. The reflected portion of the incident light is also separately named the *reflection loss* [13,18]. The reflection losses directly reduce the *Isc* of solar cells. Similarly, the finite thickness or geometry of the solar cell contributes to *transmission losses* in a PV cell [13,18]. In a wafer-based solar cell, the part of the cell that makes contact with the front side of the cell (from where light enters) is made of a finger and bus bar. These metal contacts shadow some light, which can be up to 10% [16–18]. Such losses tend to create *area losses/losses due to metal coverage*.

The photons on the solar cell generate electron–hole pairs, and these generated carriers need to be separated in order to reach their respective metal contacts before they recombine. The recombination of the carriers can be attributed to *recombination losses* in a solar cell. Recombination losses can be further classified as (i) surface recombination; (ii) bulk recombination; (iii) depletion region recombination; and (iv) recombination at the metal contacts [19].

#### *2.2. Photovoltaic Array Losses*

Under same environmental conditions/STC, identical PV cell/module/arrays sometimes exhibit un-identical *Pmp* values because of manufacturing errors that can be attributed as *mismatch power loss* [20]. It is to be noted that under heterogeneous irradiation conditions (partial shading), mismatch power loss is modeled separately due to variation in the module performance/physical environments.

The accumulation of dust over the surface of the PV module results in reduced photogenerated power and also affects the angle of incidence reaching the absorber layer of the solar cell. Such losses are referred to as *dust accumulation losses* [21]. Besides these varied irradiance values that accumulate over time, irradiance losses and temperature impacts (hot spot issues), temperature losses, and DC wiring ohmic losses seriously affect the power conversion efficiency of PV modules [22,23].

#### *2.3. System-Level Losses*

On a system level, the *inverter losses, batter losses, maximum power point tracking* (*MPPT*) *topology losses*, and potential-induced degradation or polarization losses are among the major types of PV system losses that result in reduced PV system performance over time [24,25].

For better understanding, the above-mentioned PV cell system losses have been shown pictorially in Figure 2.

**Figure 2.** Characterization of losses in a photovoltaic system: cell to system level.

#### **3. Possible Ways to Combat Losses**

#### *3.1. Addressing Photovoltaic Cell-Level Losses*

The *below energy band gap*, *thermalization*, *Fermi level losses*, and *etendue losses* can be addressed by employing an absorber layer material with low *Eg* or multi-junction approaches. In emerging PV technology, tuning the energy bandgap of organic/inorganic absorber layer properties can be useful to combat the above-mentioned issues. The *optical* and *reflection losses* can be addressed by using surface texturing and anti-reflective coatings (the material should have good transmittance). The *transmission losses* can be addressed by employing an appropriate wafer geometry and thickness to absorb the maximum amount of incident light wavelengths. The *area losses* can be mitigated by reducing the widths of the finger over the top surface while expanding the contact size of the back metal. The *surface recombination losses* can be reduced by passivating the surface to reduce dangling bonds or by adopting a window layer to limit the path of the minority charge carriers at the maximum amount. *Depletion region recombination losses* are not the most prominent type of loss. *Bulk recombination losses* can be addressed by using a pure semi-conductor material while rear surface passivation approaches could aid in combating metal contact recombination sites [11–19].

#### *3.2. Addressing Photovoltaic Array Losses*

The *mismatch power losses* can be addressed via the application of by-pass/blocking diodes or cell-cutting approaches. The *dust accumulation losses* can be addressed by properly cleaning the PV module with demineralized water or with an electro-static cleaning system. The *temperature losses* can be addressed by considering appropriate module technology (crystalline, crystalline PERC, thin-film), while DC wiring losses can be mitigated by using wires with good conductance and a minimum number of connections [20–25].

#### *3.3. System-Level Losses*

With the employment of efficient power electronic-aided topologies, inverter, MPPT, and polarization losses can be addressed [25,26]. Proper battery sizing, advancement towards dry batteries rather than lead–acid Batteries, and moderate temperature, battery dispatch strategies can aid in mitigating *battery losses* in PV systems [27].

#### **4. Conclusions**

Depending on the nature of the losses experienced in a PV system reported in the literature, we broadly and briefly classified the major types of losses that are responsible for the reduced efficacy of whole PV systems at the PV cell level, array level, and system level and presented them in a pictorial form. Further, we discussed potential solutions to overcome fundamental and extended losses in PV systems. This illustration may become a brief and useful guide to create awareness of issues that may occur at the PV cell fabrication level and how they affect the whole PV system.

**Author Contributions:** Conceptualization, F.S., A.Z.; methodology, F.S., A.Z.; validation, F.S., A.Z.; formal analysis, F.S., A.Z.; investigation, F.S., A.Z.; writing—original draft preparation, F.S., A.Z.; writing—review and editing, F.S., A.Z.; visualization, F.S., A.Z. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding.

**Data Availability Statement:** Not applicable.

**Conflicts of Interest:** The authors declare no conflict of interest.

#### **References**

