*Review* **Antimicrobial and Antibiofilm Coating of Dental Implants—Past and New Perspectives**

**Guilherme Melo Esteves <sup>1</sup> , João Esteves <sup>1</sup> , Marta Resende <sup>1</sup> , Luzia Mendes <sup>1</sup> and Andreia S. Azevedo 2,3,4,\***


**Abstract:** Regarded as one of the best solutions to replace missing teeth in the oral cavity, dental implants have been the focus of plenty of studies and research in the past few years. Antimicrobial coatings are a promising solution to control and prevent bacterial infections that compromise the success of dental implants. In the last few years, new materials that prevent biofilm adhesion to the surface of titanium implants have been reported, ranging from improved methods to already established coating surfaces. The purpose of this review is to present the developed antimicrobial and antibiofilm coatings that may have the potential to reduce bacterial infections and improve the success rate of titanium dental implants. All referred coating surfaces showed high antimicrobial properties with effectiveness in biofilm control, while maintaining implant biocompatibility. We expect that by combining the use of oligonucleotide probes as a covering material with novel peri-implant adjuvant therapies, we will be able to avoid the downsides of other covering materials (such as antibiotic resistance), prevent bacterial infections, and raise the success rate of dental implants. The existing knowledge on the optimal coating material for dental implants is limited, and further research is needed before more definitive conclusions can be drawn.

**Keywords:** oral biofilm; dental implants; titanium implants; antimicrobial; surface coating; anti-fouling
