**Preface to "Treatments for Squamous Cell Cancer"**

Squamous cell cancer (SCC) is the most frequent solid cancer. SCC is a malignant tumor of epidermal keratinocytes and consists of a disease spectrum ranging from hyperplasia, dysplasia, and carcinoma in situ to locally invasive and, finally, metastatic disease. The common risk factors for SCC initiation and progression include environmental insults such as UV irradiation; tobacco smoke and frequent alcohol use; poor hygiene; human papillomavirus (HPV) infections; lack of dietary nutrients; and immunosuppression and genetic predisposition. Considering these differing etiologies, it is not surprising that SCC is a highly heterogeneous disease.

This reprint presents our current understanding of predisposing factors and biological mechanisms that underlie heterogeneous SCC development and highlight recent preclinical and clinical advances for the effective prevention and treatment of the disease.

> **Charbel Darido** *Editor*
