**2. Methods**

This systematic review is structured following the general principles published in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines [21]. The PRISMA checklist was detailed in Table S1. Full details of the search strategies were specified and documented in a protocol that was registered at PROSPERO (https://www.crd.york.ac.uk/PROSPERO; accessed on 24 December 2020) as CRD42020223968.

## *2.1. Eligibility Criteria*

The eligibility criteria are outlined using the PICOS format (Table 1).


**Table 1.** PICOS criteria for inclusion of studies.

exclusion criteria were the following: (1) Non-English articles; (2) in vitro models; (3) review articles; (4) not fulfillingtheinclusioncriteria.
