**Preface to "Personalized Diagnosis and Therapy for Multiple Sclerosis"**

This Special Issue reprint, entitled "Personalized Diagnosis and Therapy for Multiple Sclerosis", will help the clinician working regularly with people who suffer from multiple sclerosis (MS), thanks to the excellent work of all the authors who have contributed to its realization. This reprint issue offers key concepts, practical statements and a therapeutic algorithm seeking to standardize the care process for MS relapse, as well as a critical narrative review of the evidence to determine whether it is better to offer our patients escalation therapy or early intense therapy to prevent long-term outcomes. Biomarker research conducted by our colleagues evaluating CD49d saturation under natalizumab treatment can be used to optimize an individual's dosing schedule and thereby reduce the risk of progressive multifocal leukoencephalopathy.

From the clinical point of view, in this Special Issue we explain predictors of cognitive impairment, helpful to identify patients at risk, and also confirm the presence of cognitive impairment in patients with neuromyelitis optica spectrum disorder. On the other hand, we aim to boost the field of machine learning for cognitive prognosis that until now has been largely overlooked.

Because the patient is also the guardian of his or her own health, we must explain to the patient the evidence that lifestyle behaviors are associated with quality of life and encourage him or her to adhere to these behaviors.

Finally, the results of the studies carried out demonstrate that longitudinal clinical monitoring using real-time audiovisual teleconsultation over the internet is feasible and well-received by patients with MS and that such an approach can be a promising new care strategy not only in the short term but also in the long term.

We believe that the papers in this Special Issue reprint reflect our interest in conducting research for people with MS rather than conducting research about MS.

> **Cristina M. Ramo-Tello** *Editor*
