**5. Conclusions**

The CONUT score represents a relatively new screening tool, easily applicable in clinical practice with a possible prognostic role in the management of patients with advanced thyroid cancer treated with TKIs.

Based on this evidence, the nutritional status should be taken into account in metastatic thyroid cancer patients, since the efficacy of anticancer treatments could potentially be impaired by malnutrition. The improvement in the nutritional status of cancer patients before starting and/or during TKI treatment could be one of the strategies to obtain the maximum efficacy of anticancer therapy. This study shows promising and innovative results, opening the way to future prospective studies on a larger sample size to strengthen the correlation between the nutritional status, evaluated at baseline and during cancer treatment, and the response to TKI treatment in patients with advanced thyroid cancer.

**Supplementary Materials:** The following supporting information can be downloaded at: https:// www.mdpi.com/article/10.3390/cancers14030724/s1, Table S1: CONUT score cut-offs according to ROC analysis for Progression Free Survival (a) and Overall Survival (b); Table S2: Clinical-pathological features in thyroid cancer patients with CONUT score <3 (Group 1) and ≥3 (Group 2).

**Author Contributions:** Conceptualization, C.C., M.G.C., L.B. and C.D.; Methodology, M.G.C. and L.B.; Validation, M.G.C. and L.B.; Resources L.B. and C.D.; Formal analysis, A.C., M.G.C., L.B., C.D. and M.C.; Investigation, M.G.C. and L.B.; Data curation C.D., M.C. and L.B.; Writing—original draft preparation, M.G.C., L.B., C.D. and M.C.; Visualization, C.D. and M.C.; Supervision, M.G.C. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding.

**Institutional Review Board Statement:** The study was conducted in accordance with the Declaration of Helsinki, and approved by the local Ethics Committee of Azienda Ospedaliera Universitaria Senese, Siena, Italy (protocol code # 10167/2016, 17 October 2016).

**Informed Consent Statement:** The patients provided their written informed consent to participate in this study.

**Data Availability Statement:** Data are contained within the article.

**Conflicts of Interest:** The authors declare no conflict of interest.
