4.4.1. RECIST 1.1

The implementation of the evaluation criteria RECIST 1.1 is based on the original publication of Eisenhauer et al. [15]. RECIST 1.1 was performed by an experienced radiologist using mint Lesion version 3.7 software (Mint Medical GmbH, Heidelberg, Germany) without knowledge of the results of the PET studies. A maximum of 3 to 5 target lesions were measured (max. 2 target lesions per organ) and at least 2 non-target lesions at baseline, 3 month and 6 month follow-up CT-scans. Time-point responses were then evaluated automatically. A relative increase of 20% and an absolute increase of at least 5 mm in target sum were considered as PD, while a decrease of 30% in target sum was considered PR.
