**3. Literature Search Strategy**

6K W We conducted a comprehensive literature review from the PubMed, Web of Science and Google Scholar databases for papers published before February 2021, independently. English-language filters were applied in the process of searching. Standard searches were done with the following keywords: 'thyroid cancer', 'differentiated thyroid cancer', 'thyroid nodules', and 'radiomics'. The reference lists were manually checked to identify additional relevant studies. We followed The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines to select relevant studies [52] (Figure 2).

**Figure 2.** Flow diagram for the identification and exclusion of studies in radiomics application in differentiated thyroid cancer and nodules. Abbreviations: DTC—differentiated thyroid cancer; CAD—computer-aided detection; CNN convolutional neural networks; AI—artificial intelligence.
