*2.2. Assessments and Definitions*

We evaluated in all patients the following anthropometric parameters: weight, height, and body mass index (BMI). The weight (kilograms) and height (meters) were measured using a scale with an altimeter (Seca-Intermed, Milan, Italy). The BMI was calculated as 'weight over height square'.

At baseline (before starting TKI treatment), fasting venous blood sample was collected for biochemical tests including albumin, total cholesterol, and total lymphocyte count. The concentration of such parameters was measured with standard colorimetric methods using the Cobas c 701/702 analyzer (Roche/Hitachi, Mannheim, Germany). The CONUT score was defined as the sum of the following parameters, as described below:


Radiological evaluation was performed at baseline (before treatment) and on average every 3–6 months thereafter with computed tomography (CT) scanning with contrast medium or magnetic resonance imaging (MRI).

The time from TKI administration to the first evidence of tumor progression or until death defines the progression free survival (PFS). Tumor progression was documented by CT or MRI examination according to Response Evaluation Criteria in Solid Tumors (RECIST) v 1.1. Best response (BR) was defined as the best response recorded from the start of the treatment until disease progression. The time from the start date of the TKI treatment to the time of death from any cause defines the overall survival (OS).
