*4.2. Clinical Data*

The phenotype leading to the suspicion of a *RET* variant in the family, and therefore the reason for *RET* analysis, was known for 140 of the 163 analyzed subjects. Of these, main clinical information regarding families with MTC, including disease status, age at diagnosis and family history, was available for all the patients who came to our clinic for genetic counseling and for the other 15 subjects sent from external physicians. This and any other information, such as stage of MTC, survival status and presence of any further pathologies, was collected during genetic counseling and/or derived from medical records and pathology reports.
