*4.5. Statistical Analysis*

All available data were entered anonymously into a dedicated database and were analyzed by using the statistical package IBM-SPSS Statistics (Ver. 25 for Windows, IBM Co., Armonk, NY, USA). Means, standard deviation (SD), ranges and frequencies were used as descriptive statistics. The Fisher's exact test was used for dichotomous variables and the independent t-test to analyze differences between two group means. Two-tailed *p* values lower than 0.05 were considered statistically significant. For the analysis, carriers of the p.Ser904Phe variant were included in the MOD category and the carrier of p.Asp631\_Leu633delinsGlu variant in the HST/H category. Carriers of the other VUS were excluded from the analysis.
