*2.2. Pilot-Plant Scale Extraction*

Grape cane extraction was performed on a pilot-plant scale (750 L) at 80 ◦C for 100 min, following our previously reported extraction process [2].

After winter pruning, we collected a total of 500 kg of wet sample grape canes (*V. vinifera* L. cv. Pinot noir) from plants in an organic vineyard at Viña De Neira, located in Ránquil, Itata Valley, Biobio Region, Chile. All samples were cut into 30–50 cm long pieces and stored for three months at room temperature (19 ◦C ± 5) and 30–70% relative humidity, according to previous reports by Riquelme et al. [16] and Patent [13]. We used 67 kg of dry grape canes from a total sample of 500 kg of wet samples for the pilot-plant extraction, before which grape canes were crushed in a Retsch grinder (model SM) at 300–2000 rpm until particle size was less than 1 cm. After extraction, the ethanol used as a solvent for the extraction was removed and recovered by distillation (absolute pressure 0.05 bar). The liquid extract was collected in a dark container and protected from light.

## *2.3. Preparation of Microcapsules by Spray-Drying*

The GCPPE was in a mixed ethanol/water solution (30:70 *v*/*v*). HP-*β*-CD was used to prepare the microcapsules in a proportion of 2.2% *w*/*v* with the extract. MD in a proportion of 10% *w*/*v* was used as the coating material. HP-*β*-CD was slowly added to a beaker containing 200 mL of GCPPE to avoid its agglomeration. The mixture was continuously stirred at room temperature and protected from the light for 24 h, during which the encapsulation took place. Then, MD was added slowly, and the mixture was stirred for a few minutes [17]. The microencapsulated and unencapsulated GCPPE were dried using a Büchi Mini Spray Dryer B-290 (Büchi, Flawil, Switzerland). Inlet temperature was maintained at 130 ◦C, while the outlet air temperature was 71 ◦C. Air inlet and airflow were 35–40 m3/h and 473 L/h, respectively. The spray dryer was equipped with a nozzle tip diameter of 0.7 mm and a peristaltic pump operated at 6–7 mL/min. The dried powder was collected and stored in an amber airtight container at 4 ◦C until analysis.
