**4. Conclusions**

*Spirulina plantensis* hydrolysate was successfully encapsulated into nanoliposomes using the thin-layer hydration method of sonication. This study shows that stabilizing the liposome structure with γ-oryzanol and covering the liposomes with a polycationic chitosan polymer provided long-term physical stability, and the system preserved its antioxidant capacity over time. Thus, this study suggests that chitosomes stabilized with γ-oryzanol could be used as a promising delivery system to protect against the loss of hydrolysate under processing or storage conditions.

**Author Contributions:** Methodology, M.M.; formal analysis, M.M. and R.S.; data curation and preparation, M.M.; Project administration, H.H.; writing—original draft preparation, M.M. and R.S.; Review and editing, H.H., M.G., M.P., and J.M.L. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding.

**Institutional Review Board Statement:** Not applicable.

**Informed Consent Statement:** Not applicable.

**Data Availability Statement:** Data is contained within the article.

**Acknowledgments:** The authors would like to acknowledge the Drug Applied Research Center, Tabriz University of Medical Sciences, for financial support.

**Conflicts of Interest:** The authors declare no conflict of interest.
