*Review* **What Are the Synergies between Paleoanthropology and Brain Imaging?**

**Antoine Balzeau 1,2,\* and Jean-François Mangin 3**

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	- DepartmentofAfricanZoology,RoyalMuseumforCentralAfrica,3080Tervuren,Belgium
	- Baobab Research Unit, CEA, CNRS, Neurospin Department, Université Paris-Saclay,
	- 91191 Gif-sur-Yvette, France; jean-francois.mangin@cea.fr Correspondence:abalzeau@mnhn.fr

**Abstract:** We are interested here in the central organ of our thoughts: the brain. Advances in neuroscience have made it possible to obtain increasing information on the anatomy of this organ, at ever-higher resolutions, with different imaging techniques, on ever-larger samples. At the same time, paleoanthropology has to deal with partial reflections on the shape of the brain, on fragmentary specimens and small samples in an attempt to approach the morphology of the brain of past human species. It undeniably emerges from the perspective we propose here that paleoanthropology has much to gain from interacting more with the field of neuroimaging. Improving our understanding of the morphology of the endocast necessarily involves studying the external surface of the brain and the link it maintains with the internal surface of the skull. The contribution of neuroimaging will allow us to better define the relationship between brain and endocast. Models of intra- and inter-species variability in brain morphology inferred from large neuroimaging databases will help make the most of the rare endocasts of extinct species. We also conclude that exchanges between these two disciplines will also be beneficial to our knowledge of the *Homo sapiens* brain. Documenting the anatomy among other human species and including the variation over time within our own species are approaches that offer us a new perspective through which to appreciate what really characterizes the brain of humanity today.

**Keywords:** brain-endocast correspondence; paleontology; interdisciplinarity; artificial intelligence
