**3. Results**

Our CPGs confirmed 15 recommendations based on the 7 types of KM treatments containing interventions, comparators, level of evidence, and grade of recommendation for the key clinical questions (Table 3). PRISMA flow charts and the GRADE data including the outcome measures, risk of bias, inconsistency, indirectness, imprecision, and other considerations are summarized in the Supplementary Materials S2. The details of recommendation and clinical findings, including the number of patients, number of studies, and pooled relative effect with p values extracted from all the included studies, are summarized in the Supplementary Materials S3.

**Table 3.** Interventions, comparators, and level of evidence/grade of recommendation for the key clinical questions.


