*4.1. Limitations of the Present Guidelines*

Our CPGs have several limitations. First, there are limitations in the search strategy. Since the terms were not the same for each treatment intervention, it was difficult to present a standardized method for selecting a search word, and there were limitations in establishing a consistent level of search strategy due to the different terms by country.

Second, there are some qualitative limitations that include cases where bias risk evaluation factors were not presented, cases that were not blinded, and cases where there were limitations in the design of the study. Moreover, some studies had limitations, such as study inconsistency and imprecision, and a lack of evaluation indicators, such as segmentation, safety, and economics.

Finally, there are methodological limitations that do not reflect the diversity of KM treatment techniques. Few studies have compared and analyzed the detailed elements of KM treatments. There may be some disparity from the actual clinical practice in the method of synthesizing KM treatments, including various detailed attributes, into a certain category and arriving at a conclusion. Except for the diagnosis of LHIVD, there is insufficient evidence to consider clinical variables, such as severity.
