*2.3. Assessment of the Risk of Bias in Included Studies*

Two authors independently assessed the methodological quality of each included clinical trial, according to the Cochrane risk of bias tool for randomized controlled trials (RoB 2.0) [18]. RoB 2.0 is composed of five domains, including bias arising from the randomization process (allocation), bias due to deviations from the intended interventions (performance), bias due to missing outcome data (follow-up), bias in the outcome measurement (measurement), and bias in the selection of the reported results (reporting). The authors rated each domain as either low risk, some concerns (uncertain risk of bias), or high risk. Discrepancies were resolved by the third reviewer.
