**Yin-Tso Liu 1,2, Disline Manli Tantoh 3,4, Lee Wang 4, Oswald Ndi Nfor 4, Shu-Yi Hsu 4, Chien-Chang Ho 5,6, Chia-Chi Lung 4, Horng-Rong Chang 7,8,\* and Yung-Po Liaw 3,4,\***


Received: 5 March 2020; Accepted: 27 April 2020; Published: 2 May 2020

**Abstract:** A complex interplay of several genetic and lifestyle factors influence coronary heart disease (CHD). We determined the interaction between coffee consumption and the *tribbles pseudokinase 1* (*TRIB1*) rs17321515 variant on coronary heart disease (CHD). Data on CHD were obtained from the National Health Insurance Research Database (NHIRD) while genotype data were collected from the Taiwan Biobank (TWB) Database. From the linked electronic health record data, 1116 individuals were identified with CHD while 7853 were control individuals. Coffee consumption was associated with a lower risk of CHD. The multivariate-adjusted odds ratio (OR) and 95% confidence interval (CI) was 0.84 (0.72–0.99). Association of CHD with the *TRIB1* rs17321515 variant was not significant. The OR (95% CI) was 1.01 (0.72–0.99). There was an interaction between *TRIB1* rs17321515 and coffee consumption on CHD risk (*p* for interaction = 0.0330). After stratification by rs17321515 genotypes, coffee drinking remained significantly associated with a lower risk of CHD only among participants with GG genotype (OR, 0.62; 95% CI, 0.45–0.85). In conclusion, consumption of coffee was significantly associated with a decreased risk of CHD among Taiwanese adults with the *TRIB1* GG genotype.

**Keywords:** coffee drinking; TRIB1; rs17321515; CHD; Taiwan Biobank
