*Review* **Overview of the Analytes Applied in Genotypic HIV Drug Resistance Testing**

**Hezhao Ji 1,2,\* and Paul Sandstrom 1,2**


**Abstract:** The close monitoring of HIV drug resistance using genotypic HIV drug resistance testing (HIVDRT) has become essential for effective HIV/AIDS managemen<sup>t</sup> at both individual and population levels. Over the years, a broad spectrum of analytes or specimens have been applied or attempted in HIVDRT; however, the suitability and performance of these analytes in HIVDRT and the clinical relevance of the results from them may vary significantly. This article provides a focused overview of the performance, strengths, and weaknesses of various analytes while used in HIVDRT, which may inform the optimal analytes selection in different application contexts.

**Keywords:** HIV; drug resistance; testing; analytes; specimens; performance
