*Article* **Is the Secret in the Gut? SuperJump Activity Improves Bone Remodeling and Glucose Homeostasis by GLP-1 and GIP Peptides in Eumenorrheic Women**

**Sonya Vasto <sup>1</sup> , Alessandra Amato <sup>2</sup> , Patrizia Proia 2,\* and Sara Baldassano 1,\***


**Simple Summary:** We previously showed that SuperJump activity, an innovative workout training performed on an elastic minitrampoline, exerts osteogenic action in women. The present study analyzed whether the gut peptides (GLP-1, GIP, GLP-2, PYY, ghrelin) are involved in the mechanism of action. This is because there is a link between gut peptides and bone. In fact, ingestion of a meal induces secretion of the gut peptides that act by decreasing bone resorption and blood glucose level. After 20 weeks of SuperJump activity GLP-1 and GIP levels were significantly increased while fasting insulin, glucose, insulin resistance, were significantly reduced. The study suggests that GLP-1, and GIP are involved in the mechanism of action that improves bone health and blood glucose level following 20 weeks of SuperJump activity in women.

**Abstract:** We showed that twenty weeks of SuperJump activity, an innovative workout training performed on an elastic minitrampoline, reduced bone resorption and increased bone formation in eumenorrheic women acting on the key points of the regulation of bone metabolism. The present study analyzed whether the gastrointestinal hormones are involved in the mechanism of action and if it has an impact on glucose homeostasis. The control group was composed of twelve women, similar to the exercise group that performed SuperJump activity for twenty weeks. The analysis was performed on blood samples and investigated GLP-1, GIP, GLP-2, PYY, ghrelin, glucose, insulin, insulin resistance, β-cell function, and insulin sensitivity. The results showed that the activity contributes to raising the GLP-1and GIP levels, and not on GLP-2, PYY, and ghrelin, which did not change. Moreover, SuperJump activity significantly reduced fasting insulin, glucose, insulin resistance, and increased insulin sensitivity but did not affect beta cell function. These data suggest that GLP-1, and GIP are involved in the mechanism of action that improves bone and glucose homeostasis following 20 weeks of SuperJump activity in eumenorrheic women.

**Keywords:** biological mechanisms; physical health; sports and exercise physiology; glucagon-like peptide-1; glucose-dependent insulinotropic polypeptide
